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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
IAAAVIGLGAVGGIGFLAYAWYPAIAPIPRPAASSFSADAISRGEIVANGGYCAECHTRVDGKPGPELAGDFKMATPFGD
IFSSNITPDEEWGIGNWSLAAFKRAMNKGIARDGSQLYPAFPFDHFTKVSDQDVSDLYAYLMTRPAVHLKPRDNTVPFPI
NIRLIGQGFWKLLFFTPGRYQNDPKHDAQWNRGAYLAEGNEHCGACHTPRNLLGAEKMSSVYDGAVIDGWIAPPLNDHNP
TPVVWTEDELFQYLRFGVAPLHGSAAGPMSPVPHRFLSKIPEEDVHAIAHYYADVDKAAQRSSGDQAAITRAMQMSGRDL
TGPQPLDEDARLYQGACGACHYNSGPNPVLGRPELALNNALWLDEPNNLYQVMLHGITAEEGQDHISMPSFYSGLSDHDM
ARIAAYLRRTRTTLPPWTDLEKKAASARATLEAPPVNASH

The query sequence (length=440) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8gy3:A 440 440 1.0000 1.0000 1.0000 0.0
2 7w2j:C 418 380 0.3227 0.3397 0.3737 5.18e-70 8jej:C, 8jek:C, 8k6j:C, 8k6k:C, 7w2j:F, 7wsq:C, 7wsq:F, 8xcm:C, 8xcn:C
3 8gy2:B 433 387 0.2841 0.2887 0.3230 2.48e-53
4 8hdd:B 121 79 0.0659 0.2397 0.3671 7.18e-09
5 4ax3:D 457 111 0.0705 0.0678 0.2793 8.52e-04 4ax3:A, 4ax3:B, 4ax3:C, 6f1q:A, 6fja:A, 5obo:A, 5ocb:A, 5ocf:A, 8qgf:A, 6qpt:A, 6qpt:B, 6qpt:C, 6qpt:D, 6qpt:E, 6qpt:F, 6qpu:A, 6qpu:B, 6qpu:C, 6qpu:D, 6qpu:E, 6qpu:F, 6qpv:A, 6qpv:I, 6qpx:A, 6qpx:I, 6qpz:A, 6qpz:I, 6qq0:A, 6qq1:A, 6qq2:A, 7qq2:A, 7r2u:A, 2yqb:A, 3zbm:A, 3ziy:A
6 5djq:C 303 93 0.0568 0.0825 0.2688 0.002 5djq:M, 5djq:F, 5djq:I, 3mk7:C, 3mk7:M, 3mk7:F, 3mk7:I
7 1c6s:A 87 85 0.0636 0.3218 0.3294 0.012 6tr1:A, 6tr1:C, 6tr1:E, 6tsy:A, 6tsy:B, 6tsy:C, 6tsy:D, 6tsy:E, 6tsy:F
8 3dr0:A 93 76 0.0591 0.2796 0.3421 0.022 3dr0:B, 3dr0:C, 4eic:A, 4eid:A
9 8smr:K 181 79 0.0591 0.1436 0.3291 0.028 6q2u:A, 8smr:N, 8snh:K, 8snh:N
10 1etp:A 190 90 0.0591 0.1368 0.2889 0.11 1etp:B, 1m6z:A, 1m6z:B, 1m6z:C, 1m6z:D, 1m70:A, 1m70:B, 1m70:C, 1m70:D
11 2gc4:D 147 110 0.0682 0.2041 0.2727 0.14 2gc4:H, 2gc4:L, 2gc4:P, 2gc7:D, 2gc7:H, 2gc7:L, 2gc7:P, 1mg2:D, 1mg2:H, 1mg2:L, 1mg2:P, 1mg3:D, 1mg3:H, 1mg3:L, 1mg3:P, 2mta:C
12 8smr:G 312 85 0.0455 0.0641 0.2353 0.15
13 8gth:E 105 102 0.0727 0.3048 0.3137 0.58 8gth:A, 8gth:B, 8gth:C, 8gth:F, 8gth:D
14 1cyj:A 90 83 0.0523 0.2556 0.2771 0.59 1cyi:A
15 7y5e:GN 84 82 0.0500 0.2619 0.2683 0.63 7y5e:G2, 7y7a:G7, 7y7a:Go
16 5hc2:A 343 91 0.0682 0.0875 0.3297 0.99 5hc0:A, 5hc2:B, 5hc2:C, 5hc2:D, 5hc3:B, 5hc3:D, 5hc4:A
17 3dmi:A 87 82 0.0545 0.2759 0.2927 1.3
18 2zbo:A 86 82 0.0455 0.2326 0.2439 1.3 2zbo:C, 2zbo:E, 2zbo:G, 2zbo:I, 2zbo:K
19 1a2s:A 89 79 0.0500 0.2472 0.2785 1.5 1ced:A, 1ctj:A
20 6jlu:V 137 126 0.0727 0.2336 0.2540 1.7 8iwh:V, 8iwh:v, 6j3y:V, 6j3y:v, 6j3z:V, 6j3z:v, 6j40:V, 6j40:v, 8j5k:V, 8j5k:v, 6jlu:v, 7vd5:V, 7vd5:v
21 8i02:G 284 41 0.0318 0.0493 0.3415 2.0 8ifg:P
22 1iri:A 557 71 0.0432 0.0341 0.2676 2.1 1dqr:A, 1dqr:B, 1g98:A, 1g98:B, 1gzv:A, 1hox:A, 1hox:B, 1iri:B, 1iri:C, 1iri:D, 1koj:A, 1koj:B, 1nuh:A, 1xtb:A, 1xtb:B, 6xuh:A, 6xuh:B, 6xuh:C, 6xuh:D, 6xui:A, 6xui:B, 6xui:C, 6xui:D
23 7vzg:C 193 43 0.0341 0.0777 0.3488 2.7 7vzr:C
24 5l3z:A 280 155 0.0773 0.1214 0.2194 2.9 5l4l:A
25 1gdv:A 85 82 0.0477 0.2471 0.2561 4.2
26 6sxy:B 340 103 0.0659 0.0853 0.2816 4.4 8pc7:A, 8pc7:B, 8pc7:C, 8pc7:D, 6sxy:A, 6sya:A, 6sya:B, 6syl:A, 6syl:B
27 8yts:A 83 75 0.0455 0.2410 0.2667 4.6 8yts:B
28 3o1h:B 296 54 0.0386 0.0574 0.3148 6.0
29 1wve:C 75 43 0.0341 0.2000 0.3488 7.2 1dii:C, 1dii:D, 1diq:C, 1diq:D, 1wve:D
30 3tcf:A 517 38 0.0273 0.0232 0.3158 8.5 3tcf:B, 3tcf:C, 3tcf:D, 3tcf:E, 3tcf:F, 3tcf:G, 3tcf:H, 3tcg:A, 3tcg:B, 3tcg:C, 3tcg:D, 3tcg:E, 3tcg:F, 3tcg:G, 3tcg:H

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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