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BioLiP
Download all results in tab-seperated text for 44 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1c3r:A (2.0) BS02 TSN ? GO:0004407 ... O67135 10490031 PDBbind: -logKd/Ki=6.40, IC50=0.4uM
    2 1c3r:B (2.0) BS02 TSN ? GO:0004407 ... O67135 10490031 PDBbind: -logKd/Ki=6.40, IC50=0.4uM
    3 1t64:A (1.9) BS02 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 15242608 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    4 1t64:A (1.9) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 15242608 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    5 1t64:B (1.9) BS02 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 15242608 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    6 1t64:B (1.9) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 15242608 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    7 3c10:A (2.0) BS03 TSN 3.5.1.-
    3.5.1.98    		 N/A Q8WUI4 18285338 MOAD: ic50=0.3uM
    PDBbind: -logKd/Ki=6.52, IC50=0.3uM
    BindingDB: IC50=22nM, Ki=195nM
    8 3c10:B (2.0) BS03 TSN 3.5.1.-
    3.5.1.98    		 N/A Q8WUI4 18285338 MOAD: ic50=0.3uM
    BindingDB: IC50=22nM, Ki=195nM
    9 3c10:C (2.0) BS03 TSN 3.5.1.-
    3.5.1.98    		 N/A Q8WUI4 18285338 MOAD: ic50=0.3uM
    BindingDB: IC50=22nM, Ki=195nM
    10 3f0r:A (2.54) BS02 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 19053282 PDBbind: -logKd/Ki=6.89, Ki=130nM
    BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    11 3f0r:A (2.54) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 19053282 PDBbind: -logKd/Ki=6.89, Ki=130nM
    BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    12 3f0r:B (2.54) BS02 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 19053282 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    13 3f0r:B (2.54) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 19053282 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    14 3f0r:C (2.54) BS02 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 19053282 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    15 3f0r:C (2.54) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 19053282 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    16 4qa3:A (2.876) BS01 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 25075551 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    17 4qa3:A (2.876) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 25075551 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    18 4qa3:B (2.876) BS01 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 25075551 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    19 4qa3:B (2.876) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 25075551 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    20 5d1b:A (2.9) BS02 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 26463496 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    21 5d1b:A (2.9) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 26463496 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    22 5d1b:B (2.9) BS01 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 26463496 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    23 5d1b:B (2.9) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0000118 ... Q9BY41 26463496 BindingDB: IC50=90nM, Ki=45nM, Kd=3.9e+2nM
    24 5edu:A (2.79) BS04 TSN 3.5.1.-
    3.5.1.98    		 GO:0005515 ... P0AEX9
    Q9UBN7    		 27454933
    25 5edu:B (2.79) BS03 TSN 3.5.1.-
    3.5.1.98    		 GO:0005515 ... P0AEX9
    Q9UBN7    		 27454933 PDBbind: -logKd/Ki=8.66, Ki=2.2nM
    26 5eef:A (2.151) BS02 TSN ? N/A F8W4B7 27454933 PDBbind: -logKd/Ki=8.32, Ki=4.8nM
    27 5eef:B (2.151) BS02 TSN ? N/A F8W4B7 27454933
    28 5eek:A (1.59) BS02 TSN 3.5.1.98 N/A F8W4B7 27454933 PDBbind: -logKd/Ki=9.10, Ki=0.8nM
    29 5g0g:A (1.499) BS02 TSN ? N/A F8W4B7 27454931 MOAD: ic50=5.45nM
    30 5wgi:A (1.05) BS02 TSN ? N/A F8W4B7 29203661
    31 6hoy:A (1.7) BS03 TSN 2.3.1.-
    2.3.1.286
    2.4.2.-    		 GO:0070403 ... Q8N6T7 30395713 MOAD: Kd=33uM
    PDBbind: -logKd/Ki=4.48, Kd=33uM
    BindingDB: Kd=33000nM, Ki=2000nM
    32 6hoy:B (1.7) BS03 TSN 2.3.1.-
    2.3.1.286
    2.4.2.-    		 GO:0070403 ... Q8N6T7 30395713 MOAD: Kd=33uM
    BindingDB: Kd=33000nM, Ki=2000nM
    33 6uo2:A (1.65002) BS02 TSN ? N/A F8W4B7 31755702
    34 6uo2:A (1.65002) BS03 TSN ? N/A F8W4B7 31755702
    35 6uo2:B (1.65002) BS01 TSN ? N/A F8W4B7 31755702
    36 6uo2:B (1.65002) BS03 TSN ? N/A F8W4B7 31755702
    37 6uo4:A (1.26831) BS02 TSN ? N/A F8W4B7 31755702
    38 6uo4:A (1.26831) BS03 TSN ? N/A F8W4B7 31755702
    39 6uo4:B (1.26831) BS01 TSN ? N/A F8W4B7 31755702
    40 6uo4:B (1.26831) BS03 TSN ? N/A F8W4B7 31755702
    41 6wyo:A (2.3) BS02 TSN ? N/A F8W4B7 32880591
    42 6wyo:A (2.3) BS03 TSN ? N/A F8W4B7 32880591
    43 6wyo:B (2.3) BS01 TSN ? N/A F8W4B7 32880591
    44 6wyo:B (2.3) BS03 TSN ? N/A F8W4B7 32880591
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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