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BioLiP
Download all results in tab-seperated text for 21 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1mrn:A (2.45) BS02 T5A 2.7.4.9 GO:0000287 ... P9WKE1 12454011 MOAD: Ki=30uM
    PDBbind: -logKd/Ki=4.52, Ki=30uM
    2 1p75:A (3.02) BS01 T5A 2.7.1.21 GO:0004797 ... P24425 14527394
    3 1p75:B (3.02) BS01 T5A 2.7.1.21 GO:0004797 ... P24425 14527394
    4 1p75:C (3.02) BS01 T5A 2.7.1.21 GO:0004797 ... P24425 14527394
    5 1p75:D (3.02) BS01 T5A 2.7.1.21 GO:0004797 ... P24425 14527394
    6 1p7c:A (2.1) BS01 T5A 2.7.1.21 GO:0004797 ... P0DTH5 14527394
    7 2wwh:A (2.7) BS01 T5A 2.7.4.8
    2.7.4.9    		 GO:0004385 ... Q8I4S1 20353400
    8 2wwh:B (2.7) BS01 T5A 2.7.4.8
    2.7.4.9    		 GO:0004385 ... Q8I4S1 20353400
    9 2wwh:B (2.7) BS02 T5A 2.7.4.8
    2.7.4.9    		 GO:0004385 ... Q8I4S1 20353400
    10 2wwh:C (2.7) BS01 T5A 2.7.4.8
    2.7.4.9    		 GO:0004385 ... Q8I4S1 20353400
    11 3tmk:A (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    PDBbind: -logKd/Ki=6.87, Kd=135nM
    12 3tmk:B (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    13 3tmk:C (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    14 3tmk:D (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    15 3tmk:E (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    16 3tmk:F (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    17 3tmk:G (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    18 3tmk:H (2.0) BS01 T5A 2.7.4.9 GO:0004550 ... P00572 9521686 MOAD: Kd=135nM
    19 4tmk:A (1.98) BS01 T5A 2.7.4.9 GO:0004798 ... P0A720 9826650 MOAD: Kd=20nM
    PDBbind: -logKd/Ki=7.70, Kd=20nM
    20 4uxh:A (2.4) BS01 T5A 2.7.1.21 GO:0004797 ... Q4QC75 25978379 MOAD: ic50=1.1uM
    PDBbind: -logKd/Ki=5.96, IC50=1.1uM
    21 4uxh:B (2.4) BS01 T5A 2.7.1.21 GO:0004797 ... Q4QC75 25978379 MOAD: ic50=1.1uM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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