Home Research COVID-19 Services Publications People Teaching Job Opening News Forum --> -->
Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 15 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

    • Sort results by
    << < 1 > >>
    Go to page

    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 3ama:A (1.75) BS02 SKE 2.7.11.11 GO:0000287 ... P17612 21774789 MOAD: Ki=0.297uM
    PDBbind: -logKd/Ki=6.53, Ki=0.297uM
    BindingDB: Kd=>10000nM
    2 4qmu:A (1.546) BS01 SKE 2.7.11.1 GO:0004672 ... Q9Y6E0 27135311 MOAD: ic50=1.3uM
    PDBbind: -logKd/Ki=5.89, IC50=1.3uM
    BindingDB: Kd=180nM
    3 5dpv:A (2.285) BS02 SKE 2.7.11.1 GO:0004672 ... O14965 27339427 BindingDB: Kd=250nM, IC50=11nM
    4 5dr6:A (2.534) BS02 SKE 2.7.11.1 GO:0004672 ... O14965 27339427 BindingDB: Kd=250nM, IC50=11nM
    5 5dr9:A (2.47) BS01 SKE 2.7.11.1 GO:0004672 ... O14965 27339427 BindingDB: Kd=250nM, IC50=11nM
    6 5dt0:A (2.15) BS01 SKE 2.7.11.1 GO:0004672 ... O14965 27339427 BindingDB: Kd=250nM, IC50=11nM
    7 5obr:A (2.62) BS02 SKE 2.7.11.1 GO:0000212 ... O14965 28787041 BindingDB: Kd=250nM, IC50=11nM
    8 5usy:A (2.0) BS01 SKE 2.7.10.2 GO:0004672 ... O60674 28626521 PDBbind: -logKd/Ki=7.51, Kd=31nM
    BindingDB: Kd=220nM, IC50=2960nM, Ki=220000nM
    9 5usy:B (2.0) BS01 SKE 2.7.10.2 GO:0004672 ... O60674 28626521 BindingDB: Kd=220nM, IC50=2960nM, Ki=220000nM
    10 5usz:A (2.103) BS01 SKE 2.7.10.2 GO:0004672 ... O60674 28626521 MOAD: Kd=106nM
    PDBbind: -logKd/Ki=6.97, Kd=106nM
    BindingDB: Kd=220nM, IC50=2960nM, Ki=220000nM
    11 5win:A (2.38) BS01 SKE 2.7.10.2 GO:0004672 ... O60674 30763067 PDBbind: -logKd/Ki=7.03, Kd=94nM
    BindingDB: Kd=220nM, IC50=2960nM, Ki=220000nM
    12 6drw:A (2.303) BS01 SKE 2.7.10.2 GO:0004672 ... O60674 N/A BindingDB: Kd=220nM, IC50=2960nM, Ki=220000nM
    13 6p10:B (2.301) BS01 SKE 5.6.1.1 GO:0005524 ... Q8I0P1 31257183 MOAD: ic50=6uM
    PDBbind: -logKd/Ki=5.22, IC50=6.0uM
    14 6p11:B (2.15) BS01 SKE 5.6.1.1 GO:0005524 ... Q8I0P1 31257183 MOAD: ic50=0.9uM
    PDBbind: -logKd/Ki=6.05, IC50=0.9uM
    15 8b99:A (1.6) BS01 SKE 2.7.10.2 GO:0004672 ... O60674 36678572
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

    • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218