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BioLiP
Download all results in tab-seperated text for 44 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1c9h:A (2.0) BS01 RAP 5.2.1.8 GO:0002027 ... P68106 10713512 BindingDB: Kd=0.200000nM
    2 1fap:A (2.7) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 8662507 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    3 1fap:B (2.7) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 8662507 BindingDB: IC50=>10000nM, Kd=0.600000nM
    4 1fkb:A (1.7) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 N/A MOAD: Kd=0.2nM
    PDBbind: -logKd/Ki=9.70, Kd=0.2nM
    BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    5 1fkl:A (1.7) BS01 RAP 5.2.1.8 GO:0000413 ... P18203 15299838
    6 1pbk:A (2.5) BS01 RAP 5.2.1.8 GO:0003755 ... Q00688 N/A MOAD: Ki=0.9nM
    PDBbind: -logKd/Ki=9.05, Ki=0.9nM
    7 2dg3:A (1.7) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 12600203 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    8 2dg4:A (1.7) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 12600203 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    9 2dg9:A (1.7) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 12600203 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    10 2vcd:A (-1.00) BS01 RAP 5.2.1.8 GO:0003755 ... Q5ZXE0 18366641
    11 3kz7:A (1.95) BS01 RAP 5.2.1.8 GO:0003755 ... Q62446 24879919
    12 4drh:A (2.3) BS01 RAP 5.2.1.8 GO:0003755 ... Q13451 23358420 BindingDB: Ki=3.0nM
    13 4drh:B (2.3) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 23358420 BindingDB: IC50=>10000nM, Kd=0.600000nM
    14 4drh:D (2.3) BS01 RAP 5.2.1.8 GO:0003755 ... Q13451 23358420 BindingDB: Ki=3.0nM
    15 4drh:E (2.3) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 23358420 BindingDB: IC50=>10000nM, Kd=0.600000nM
    16 4dri:A (1.45) BS01 RAP 5.2.1.8 GO:0003755 ... Q13451 23358420 BindingDB: Ki=3.0nM
    17 4dri:B (1.45) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 23358420 BindingDB: IC50=>10000nM, Kd=0.600000nM
    18 4drj:A (1.8) BS01 RAP 5.2.1.8 GO:0003755 ... Q02790 23358420
    19 4drj:B (1.8) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 23358420 BindingDB: IC50=>10000nM, Kd=0.600000nM
    20 4qt2:A (1.44) BS01 RAP 5.2.1.8 GO:0003755 ... Q8I4V8 26057671 MOAD: ic50=0.48uM
    PDBbind: -logKd/Ki=6.32, IC50=0.48uM
    21 4qt3:A (1.4) BS01 RAP 5.2.1.8 GO:0003755 ... Q8I4V8 26057671 MOAD: ic50=0.48uM
    22 5flc:B (5.9) BS01 RAP 2.7.11.1 GO:0004674 ... P42345 26678875 BindingDB: IC50=>10000nM, Kd=0.600000nM
    23 5flc:C (5.9) BS01 RAP N/A N/A N/A 26678875
    24 5flc:F (5.9) BS01 RAP 2.7.11.1 GO:0004674 ... P42345 26678875 BindingDB: IC50=>10000nM, Kd=0.600000nM
    25 5flc:G (5.9) BS01 RAP N/A N/A N/A 26678875
    26 5gpg:A (1.67) BS01 RAP 5.2.1.8 GO:0003755 ... Q00688 27610411
    27 5gpg:B (1.67) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 27610411 BindingDB: IC50=>10000nM, Kd=0.600000nM
    28 5hkg:A (1.5) BS01 RAP 5.2.1.8 GO:0002027 ... P68106 27670942 BindingDB: Kd=0.200000nM
    29 6m4u:A (2.2) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    30 6m4u:B (2.2) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 32747768 BindingDB: IC50=>10000nM, Kd=0.600000nM
    31 6m4u:E (2.2) BS01 RAP 5.2.1.8 GO:0000413 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    32 6m4u:F (2.2) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 32747768 BindingDB: IC50=>10000nM, Kd=0.600000nM
    33 6m4v:B (2.92) BS01 RAP 5.2.1.8 GO:0003755 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    34 6m4v:D (2.92) BS01 RAP 5.2.1.8 GO:0003755 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    35 6m4w:A (3.11) BS03 RAP 5.2.1.8 GO:0003755 ... P0AEX9
    P62942    		 32747768
    36 6m4w:D (3.11) BS01 RAP 5.2.1.8 GO:0003755 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    37 6m4w:E (3.11) BS01 RAP 5.2.1.8 GO:0003755 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    38 6m4w:F (3.11) BS01 RAP 5.2.1.8 GO:0003755 ... P62942 32747768 BindingDB: IC50=0.600000nM, EC50=30nM, Ki=0.20nM
    39 6m4w:G (3.11) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 32747768 BindingDB: IC50=>10000nM, Kd=0.600000nM
    40 6m4w:H (3.11) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 32747768 BindingDB: IC50=>10000nM, Kd=0.600000nM
    41 6m4w:I (3.11) BS01 RAP 2.7.11.1 GO:0044877 ... P42345 32747768 BindingDB: IC50=>10000nM, Kd=0.600000nM
    42 7f2j:A (1.6) BS01 RAP 5.2.1.8 GO:0003755 ... Q93ZG9 35218805
    43 7f2j:B (1.6) BS01 RAP 5.2.1.8 GO:0003755 ... Q93ZG9 35218805
    44 8xi9:A (1.85) BS01 RAP N/A N/A P42345
    P62942    		 39031920
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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