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●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 392 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1hfa:A (2.0) BS01 PIO ? GO:0005543 ... O55012 11161218
    2 2h3v:A (-1.00) BS01 PIO 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0005198 ... P12497 16840558
    3 3spg:A (2.613) BS01 PIO ? GO:0005242 ... F1NHE9 21874019
    4 3sph:A (3.003) BS01 PIO ? GO:0005242 ... F1NHE9 21874019
    5 3spi:A (3.307) BS01 PIO ? GO:0005242 ... F1NHE9 21874019
    6 3sya:A (2.98) BS02 PIO ? GO:0005242 ... P48542 21962516
    7 3syq:A (3.44) BS01 PIO ? GO:0005242 ... P48542 21962516
    8 4cqk:A (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    9 4cqk:B (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    10 4cqk:B (1.6) BS02 PIO ? GO:0006952 ... Q8GTM0 24692446
    11 4cqk:C (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    12 4cqk:C (1.6) BS02 PIO ? GO:0006952 ... Q8GTM0 24692446
    13 4cqk:D (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    14 4cqk:D (1.6) BS02 PIO ? GO:0006952 ... Q8GTM0 24692446
    15 4cqk:E (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    16 4cqk:F (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    17 4cqk:G (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    18 4cqk:H (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    19 4cqk:I (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    20 4cqk:J (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    21 4cqk:K (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    22 4cqk:L (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    23 4cqk:M (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    24 4cqk:M (1.6) BS02 PIO ? GO:0006952 ... Q8GTM0 24692446
    25 4cqk:N (1.6) BS01 PIO ? GO:0006952 ... Q8GTM0 24692446
    26 4kfm:A (3.45) BS01 PIO ? GO:0005242 ... P48542 23739333
    27 4ns0:A (1.8) BS01 PIO ? GO:0016020 ... P47709 24302762
    28 4pr9:D (3.2) BS01 PIO ? GO:0003779 ... P18206 N/A
    29 4pr9:E (3.2) BS01 PIO ? GO:0003779 ... P18206 N/A
    30 4pr9:F (3.2) BS01 PIO ? GO:0003779 ... P18206 N/A
    31 5kum:A (2.8) BS01 PIO ? GO:0005242 ... F1NHE9 27527100
    32 5l0c:B (3.1) BS01 PIO ? GO:0003779 ... P18206 27503891
    33 5l0c:B (3.1) BS02 PIO ? GO:0003779 ... P18206 27503891
    34 5l0c:C (3.1) BS01 PIO ? GO:0003779 ... P18206 27503891
    35 5l0c:D (3.1) BS01 PIO ? GO:0003779 ... P18206 27503891
    36 5l0d:B (2.75) BS01 PIO ? GO:0003779 ... P18206 27503891
    37 5l0d:D (2.75) BS01 PIO ? GO:0003779 ... P18206 27503891
    38 5l0g:B (3.4) BS01 PIO ? GO:0003779 ... P18206 27503891
    39 5l0g:C (3.4) BS01 PIO ? GO:0003779 ... P18206 27503891
    40 5l0h:A (2.9) BS01 PIO ? GO:0003779 ... P18206 27503891 PDBbind: -logKd/Ki=5.64, Kd=2.3uM
    41 5lo8:A (2.5) BS03 PIO ? GO:0016020 ... P47709 28634303
    42 5lo8:B (2.5) BS01 PIO ? GO:0016020 ... P47709 28634303
    43 5lo8:B (2.5) BS04 PIO ? GO:0016020 ... P47709 28634303
    44 5on7:A (3.35) BS01 PIO ? N/A Q05785 29362354
    45 5vyp:A (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    46 5vyp:B (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    47 5vyp:C (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    48 5vyp:C (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    49 5vyp:D (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    50 5vyp:D (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    51 5vyp:D (2.6) BS03 PIO ? GO:0005773 ... C0HK49 28741756
    52 5vyp:E (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    53 5vyp:F (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    54 5vyp:G (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    55 5vyp:G (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    56 5vyp:H (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    57 5vyp:H (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    58 5vyp:H (2.6) BS03 PIO ? GO:0005773 ... C0HK49 28741756
    59 5vyp:I (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    60 5vyp:I (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    61 5vyp:J (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    62 5vyp:J (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    63 5vyp:K (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    64 5vyp:L (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    65 5vyp:L (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    66 5vyp:M (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    67 5vyp:M (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    68 5vyp:N (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    69 5vyp:N (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    70 5vyp:O (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    71 5vyp:O (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    72 5vyp:P (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    73 5vyp:P (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    74 5vyp:Q (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    75 5vyp:Q (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    76 5vyp:Q (2.6) BS03 PIO ? GO:0005773 ... C0HK49 28741756
    77 5vyp:R (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    78 5vyp:S (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    79 5vyp:S (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    80 5vyp:T (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    81 5vyp:T (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    82 5vyp:T (2.6) BS03 PIO ? GO:0005773 ... C0HK49 28741756
    83 5vyp:U (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    84 5vyp:U (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    85 5vyp:U (2.6) BS03 PIO ? GO:0005773 ... C0HK49 28741756
    86 5vyp:V (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    87 5vyp:V (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    88 5vyp:W (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    89 5vyp:X (2.6) BS01 PIO ? GO:0005773 ... C0HK49 28741756
    90 5vyp:X (2.6) BS02 PIO ? GO:0005773 ... C0HK49 28741756
    91 6cds:A (2.62) BS01 PIO ? GO:0003779 ... P35240 29626191
    92 6cds:B (2.62) BS01 PIO ? GO:0003779 ... P35240 29626191
    93 6cs9:A (1.85) BS01 PIO ? GO:0005515 ... O15263 30050988 MOAD: ic50=2.2uM
    94 6cs9:B (1.85) BS01 PIO ? GO:0005515 ... O15263 30050988 MOAD: ic50=2.2uM
    95 6cs9:B (1.85) BS02 PIO ? GO:0005515 ... O15263 30050988 MOAD: ic50=2.2uM
    96 6dmu:A (4.0) BS01 PIO ? GO:0005216 ... Q9XSM3 30305626
    97 6dmu:B (4.0) BS01 PIO ? GO:0005216 ... Q9XSM3 30305626
    98 6dmu:C (4.0) BS01 PIO ? GO:0005216 ... Q9XSM3 30305626
    99 6dmu:D (4.0) BS01 PIO ? GO:0005216 ... Q9XSM3 30305626
    100 6e7y:A (3.57) BS01 PIO ? GO:0001891 ... Q9GZU1 30305615
    101 6e7y:B (3.57) BS01 PIO ? GO:0001891 ... Q9GZU1 30305615
    102 6e7y:C (3.57) BS01 PIO ? GO:0001891 ... Q9GZU1 30305615
    103 6e7y:D (3.57) BS01 PIO ? GO:0001891 ... Q9GZU1 30305615
    104 6hug:A (3.1) BS01 PIO ? GO:0004888 ... P08219 30602790
    105 6hug:D (3.1) BS02 PIO ? GO:0004888 ... P08219 30602790
    106 6huj:A (3.04) BS01 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    107 6huj:D (3.04) BS02 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    108 6huk:A (3.69) BS02 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    109 6huk:D (3.69) BS01 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    110 6huo:A (3.26) BS02 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    111 6huo:D (3.26) BS02 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    112 6hup:A (3.58) BS01 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    113 6hup:D (3.58) BS02 PIO ? GO:0004888 ... P08219
    P14867    		 30602790
    114 6i53:A (3.2) BS01 PIO ? GO:0004888 ... P14867 30602789
    115 6i53:D (3.2) BS01 PIO ? GO:0004888 ... P14867 30602789
    116 6m84:A (2.81) BS01 PIO ? GO:0005242 ... F1NHE9 31744859
    117 6mfs:A (2.85) BS01 PIO ? GO:0005856 ... P26039 30254158
    118 6pw4:A (3.53) BS01 PIO ? GO:0005216 ... Q0Z852 31519888
    119 6pw4:C (3.53) BS01 PIO ? GO:0005216 ... Q0Z852 31519888
    120 6pw5:A (3.45) BS01 PIO ? GO:0005216 ... Q0Z852 31519888
    121 6pw5:B (3.45) BS01 PIO ? GO:0005216 ... Q0Z852 31519888
    122 6pw5:C (3.45) BS01 PIO ? GO:0005216 ... Q0Z852 31519888
    123 6pw5:D (3.45) BS01 PIO ? GO:0005216 ... Q0Z852 31519888
    124 6up7:B (4.2) BS02 PIO ? GO:0007165 ... P49407 31945771
    125 6up7:R (4.2) BS02 PIO ? GO:0004930 ... P30989 31945771
    126 6w7e:A (3.29) BS02 PIO ? GO:0005267 ... P97438 33127683
    127 6xeu:A (3.2) BS01 PIO ? GO:0005242 ... P48542 N/A
    128 6xeu:D (3.2) BS01 PIO ? GO:0005242 ... P48542 N/A
    129 6xeu:G (3.2) BS01 PIO ? GO:0005242 ... P48542 N/A
    130 6xeu:J (3.2) BS01 PIO ? GO:0005242 ... P48542 N/A
    131 6xev:A (3.5) BS01 PIO ? GO:0005242 ... P48542 N/A
    132 6xev:E (3.5) BS01 PIO ? GO:0005242 ... P48542 N/A
    133 6xev:I (3.5) BS01 PIO ? GO:0005242 ... P48542 N/A
    134 6xev:M (3.5) BS01 PIO ? GO:0005242 ... P48542 N/A
    135 6xit:A (3.3) BS01 PIO ? GO:0005242 ... P48542 32844743
    136 6xit:B (3.3) BS01 PIO ? GO:0005242 ... P48542 32844743
    137 6xit:C (3.3) BS01 PIO ? GO:0005242 ... P48542 32844743
    138 6xit:D (3.3) BS01 PIO ? GO:0005242 ... P48542 32844743
    139 7b2l:A (3.9) BS01 PIO ? N/A Q12518 34001871
    140 7b2l:A (3.9) BS02 PIO ? N/A Q12518 34001871
    141 7b2l:B (3.9) BS01 PIO ? GO:0005543 ... P33338 34001871
    142 7b2l:C (3.9) BS01 PIO ? N/A Q12518 34001871
    143 7b2l:C (3.9) BS02 PIO ? N/A Q12518 34001871
    144 7b2l:C (3.9) BS03 PIO ? N/A Q12518 34001871
    145 7b2l:F (3.9) BS01 PIO ? N/A Q12518 34001871
    146 7b2l:F (3.9) BS02 PIO ? N/A Q12518 34001871
    147 7b2l:G (3.9) BS01 PIO ? GO:0005543 ... P33338 34001871
    148 7b2l:H (3.9) BS01 PIO ? N/A Q12518 34001871
    149 7b2l:H (3.9) BS02 PIO ? N/A Q12518 34001871
    150 7b2l:H (3.9) BS03 PIO ? N/A Q12518 34001871
    151 7b2l:K (3.9) BS01 PIO ? N/A Q12518 34001871
    152 7b2l:K (3.9) BS02 PIO ? N/A Q12518 34001871
    153 7b2l:L (3.9) BS01 PIO ? GO:0005543 ... P33338 34001871
    154 7b2l:M (3.9) BS01 PIO ? N/A Q12518 34001871
    155 7b2l:M (3.9) BS02 PIO ? N/A Q12518 34001871
    156 7b2l:M (3.9) BS03 PIO ? N/A Q12518 34001871
    157 7b2l:P (3.9) BS01 PIO ? N/A Q12518 34001871
    158 7b2l:P (3.9) BS02 PIO ? N/A Q12518 34001871
    159 7b2l:Q (3.9) BS01 PIO ? GO:0005543 ... P33338 34001871
    160 7b2l:R (3.9) BS01 PIO ? N/A Q12518 34001871
    161 7b2l:R (3.9) BS02 PIO ? N/A Q12518 34001871
    162 7b2l:R (3.9) BS03 PIO ? N/A Q12518 34001871
    163 7ovr:A (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    164 7ovr:B (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    165 7ovr:C (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    166 7ovr:D (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    167 7ovr:E (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    168 7ovr:F (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    169 7ovr:H (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    170 7ovr:I (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    171 7ovr:J (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    172 7ovr:O (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    173 7ovr:P (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    174 7ovr:Q (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    175 7ovr:R (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    176 7ovr:S (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    177 7ovr:U (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    178 7ovr:W (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    179 7ovr:Y (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    180 7ovr:b (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    181 7ovr:c (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    182 7ovr:d (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    183 7ovr:e (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    184 7ovr:f (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    185 7ovr:j (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    186 7ovr:l (7.0) BS01 PIO ? GO:0005198 ... P12493 34353956
    187 7qne:A (2.7) BS01 PIO ? GO:0004888 ... P14867 35355020
    188 7qne:D (2.7) BS03 PIO ? GO:0004888 ... P14867 35355020
    189 7sku:A (2.117) BS01 PIO ? GO:0005198 ... Q9IK90 35857835
    190 7sku:B (2.117) BS01 PIO ? GO:0005198 ... Q9IK90 35857835
    191 7t6m:A (2.8) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    192 7t6m:B (2.8) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    193 7t6m:C (2.8) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    194 7t6m:D (2.8) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    195 7t6q:A (3.4) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    196 7t6q:B (3.4) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    197 7t6q:C (3.4) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    198 7t6q:D (3.4) BS01 PIO ? GO:0005216 ... Q9XSM3 35476976
    199 7tu9:A (3.0) BS02 PIO ? GO:0004888 ... O93430 N/A
    200 7tu9:D (3.0) BS02 PIO ? GO:0004888 ... O93430 N/A
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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