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BioLiP
Download all results in tab-seperated text for 26 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 3sz1:B (2.3) BS01 LU2 ? GO:0003677 ... P37231 22391103 PDBbind: -logKd/Ki=4.66, IC50=21.8uM
    2 4dew:A (1.899) BS01 LU2 ? N/A P02766 22842046 MOAD: Kd=0.1uM
    PDBbind: -logKd/Ki=7.00, Kd=0.10uM
    BindingDB: IC50=7000nM, Kd=70nM
    3 4dew:B (1.899) BS01 LU2 ? N/A P02766 22842046 MOAD: Kd=0.1uM
    PDBbind: -logKd/Ki=7.00, Kd=0.10uM
    BindingDB: IC50=7000nM, Kd=70nM
    4 4dgn:A (1.75) BS01 LU2 2.7.11.1 GO:0004672 ... P28523 22794353 MOAD: ic50=0.35uM
    PDBbind: -logKd/Ki=6.46, IC50=0.35uM
    5 4hkn:A (2.05) BS02 LU2 2.4.2.-
    2.4.2.30    		 GO:0003950 ... Q9H2K2 23574272 PDBbind: -logKd/Ki=5.96, IC50=1.1uM
    BindingDB: IC50=1100nM
    6 4qxv:A (1.12) BS01 LU2 ? GO:0005179 ... P02766 26020516 BindingDB: IC50=7000nM, Kd=70nM
    7 4qxv:B (1.12) BS01 LU2 ? GO:0005179 ... P02766 26020516 BindingDB: IC50=7000nM, Kd=70nM
    8 4qya:A (1.7) BS01 LU2 ? GO:0005179 ... P02766 26020516 BindingDB: IC50=7000nM, Kd=70nM
    9 4qya:B (1.7) BS01 LU2 ? GO:0005179 ... P02766 26020516 BindingDB: IC50=7000nM, Kd=70nM
    10 5auu:A (1.7) BS01 LU2 2.7.11.1 GO:0004672 ... P53355 26322379 MOAD: ic50=21uM
    PDBbind: -logKd/Ki=4.68, IC50=21uM
    BindingDB: IC50=21000nM
    11 5ii2:A (2.1) BS01 LU2 ? GO:0006338 ... Q86U86 27617704 PDBbind: -logKd/Ki=4.89, Kd=12.9uM
    BindingDB: Kd=12900nM
    12 5ii2:B (2.1) BS01 LU2 ? GO:0006338 ... Q86U86 27617704 BindingDB: Kd=12900nM
    13 5ndf:A (2.3) BS03 LU2 2.4.1.41 GO:0000139 ... Q10471 29061849 MOAD: Ki=1.4uM
    PDBbind: -logKd/Ki=5.85, Ki=1.4uM
    14 5ndf:B (2.3) BS03 LU2 2.4.1.41 GO:0000139 ... Q10471 29061849 MOAD: Ki=1.4uM
    15 5ndf:D (2.3) BS03 LU2 2.4.1.41 GO:0000139 ... Q10471 29061849 MOAD: Ki=1.4uM
    16 6m8a:A (1.75) BS01 LU2 2.7.1.140
    2.7.1.151
    2.7.1.153    		 GO:0016301 ... Q8NFU5 30624931 MOAD: ic50=5.5uM
    PDBbind: -logKd/Ki=5.26, IC50=5.5uM
    BindingDB: IC50=5500nM
    17 6ya5:A (2.0) BS03 LU2 3.1.-.- GO:0003723 ... C3W5X6 32883638 MOAD: ic50=0.072uM
    18 7d3b:A (2.25) BS02 LU2 ? GO:0000166 ... G9YLX2 33542233
    19 7ebv:A (1.5) BS02 LU2 2.5.1.18 N/A A0A1S4FIB3 35172816
    20 7ebv:B (1.5) BS02 LU2 2.5.1.18 N/A A0A1S4FIB3 35172816
    21 7ebv:C (1.5) BS02 LU2 2.5.1.18 N/A A0A1S4FIB3 35172816
    22 7ebv:D (1.5) BS02 LU2 2.5.1.18 N/A A0A1S4FIB3 35172816
    23 8i94:A (2.43) BS01 LU2 2.4.1.- GO:0008194 ... A0A292GEP7 38346547
    24 8i94:B (2.43) BS01 LU2 2.4.1.- GO:0008194 ... A0A292GEP7 38346547
    25 8wr2:A (1.94) BS02 LU2 2.7.1.35 GO:0000287 ... O00764 38150934
    26 8wr2:B (1.94) BS02 LU2 2.7.1.35 GO:0000287 ... O00764 38150934
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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