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BioLiP
Download all results in tab-seperated text for 71 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1ftk:A (1.6) BS01 KAI ? GO:0015276 ... P19491 11086992 MOAD: ic50=14.5uM
    PDBbind: -logKd/Ki=4.84, IC50=14.5uM
    BindingDB: EC50=380000nM, Ki=3690nM
    2 1fw0:A (1.9) BS01 KAI ? GO:0015276 ... P19491 11086992 PDBbind: -logKd/Ki=5.43, Ki=3690nM
    BindingDB: EC50=380000nM, Ki=3690nM
    3 1gr2:A (1.9) BS01 KAI ? GO:0015276 ... P19491 9804426 BindingDB: EC50=380000nM, Ki=3690nM
    4 1p1n:A (1.6) BS01 KAI ? GO:0015276 ... P19491 12730367 MOAD: Kd=0.16uM
    PDBbind: -logKd/Ki=6.80, Kd=0.16uM
    BindingDB: EC50=380000nM, Ki=3690nM
    5 1tt1:A (1.93) BS01 KAI ? GO:0015276 ... P42260 15721240 MOAD: Ki=64.6nM
    PDBbind: -logKd/Ki=8.15, IC50=0.007uM
    BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    6 1tt1:B (1.93) BS01 KAI ? GO:0015276 ... P42260 15721240 MOAD: Ki=64.6nM
    BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    7 1xhy:A (1.85) BS01 KAI ? GO:0015276 ... P19491 15591246 MOAD: Ki=624nM
    PDBbind: -logKd/Ki=6.18, Ki=662nM
    BindingDB: EC50=380000nM, Ki=3690nM
    8 2anj:A (2.1) BS01 KAI ? GO:0015276 ... P19491 16103115 BindingDB: EC50=380000nM, Ki=3690nM
    9 2xxt:A (1.9) BS01 KAI ? GO:0015276 ... P42260 21414913 PDBbind: -logKd/Ki=8.05, Kd=9.0nM
    BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    10 2xxt:B (1.9) BS01 KAI ? GO:0015276 ... P42260 21414913 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    11 2xxv:A (1.7) BS01 KAI ? GO:0015276 ... P42260 21414913 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    12 2xxv:B (1.7) BS01 KAI ? GO:0015276 ... P42260 21414913 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    13 2xxy:A (3.0) BS01 KAI ? GO:0015276 ... P42260 21414913 PDBbind: -logKd/Ki=7.89, Kd=12.9nM
    BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    14 2xxy:B (3.0) BS01 KAI ? GO:0015276 ... P42260 21414913 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    15 2xxy:C (3.0) BS01 KAI ? GO:0015276 ... P42260 21414913 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    16 2xxy:D (3.0) BS01 KAI ? GO:0015276 ... P42260 21414913 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    17 3c31:A (1.49) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    18 3c31:B (1.49) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    19 3c32:A (1.72) BS02 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    20 3c32:B (1.72) BS02 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    21 3c33:A (1.72) BS02 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    22 3c33:B (1.72) BS02 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    23 3c34:A (1.82) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    24 3c34:B (1.82) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    25 3c35:A (1.97) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    26 3c35:B (1.97) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    27 3c36:A (1.68) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    28 3c36:B (1.68) BS01 KAI ? GO:0015276 ... P22756 18549784 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    29 3en3:A (2.43) BS01 KAI ? GO:0015276 ... P19493 19102704 BindingDB: EC50=47000nM, Ki=3570nM
    30 3kfm:A (2.2) BS01 KAI ? GO:0015276 ... P19493 20107073 BindingDB: EC50=47000nM, Ki=3570nM
    31 3u92:A (1.9) BS01 KAI ? GO:0015276 ... P42264 23141068 PDBbind: -logKd/Ki=7.48, Ki=32.8nM
    BindingDB: Ki=32.8nM
    32 3u92:B (1.9) BS01 KAI ? GO:0015276 ... P42264 23141068 BindingDB: Ki=32.8nM
    33 4bdm:A (3.4) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    34 4bdm:B (3.4) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    35 4bdm:C (3.4) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    36 4bdm:D (3.4) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    37 4bdo:A (2.55) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    38 4bdo:B (2.55) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    39 4bdo:C (2.55) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    40 4bdo:D (2.55) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    41 4bdr:A (1.65) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    42 4bdr:B (1.65) BS01 KAI ? GO:0015276 ... P42260 23720540 BindingDB: Ki=12.7nM, Kd=39nM, EC50=1800nM
    43 4e0w:A (2.3501) BS01 KAI ? GO:0015276 ... P42264 22425692 PDBbind: -logKd/Ki=7.48, Ki=33nM
    BindingDB: Ki=32.8nM
    44 4e0x:A (2.0) BS01 KAI ? GO:0015276 ... P22756 22425692 PDBbind: -logKd/Ki=7.12, Ki=76nM
    BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    45 4e0x:B (2.0) BS01 KAI ? GO:0015276 ... P22756 22425692 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    46 4f22:A (2.06) BS01 KAI ? GO:0015276 ... P19492 22512472 MOAD: Ki=30.26uM
    BindingDB: EC50=40000nM, Ki=5780nM
    47 4f31:B (2.286) BS01 KAI ? GO:0015276 ... P19492 22512472 MOAD: Ki=2.08uM
    BindingDB: EC50=40000nM, Ki=5780nM
    48 4f31:D (2.286) BS01 KAI ? GO:0015276 ... P19492 22512472 MOAD: Ki=2.08uM
    BindingDB: EC50=40000nM, Ki=5780nM
    49 4f39:A (1.834) BS01 KAI ? GO:0015276 ... P19492 22512472 MOAD: Ki=3.44uM
    PDBbind: -logKd/Ki=5.70, Ki=1980nM
    BindingDB: EC50=40000nM, Ki=5780nM
    50 4f3g:A (2.064) BS01 KAI ? GO:0015276 ... P19492 22512472 MOAD: Ki=3.44uM
    BindingDB: EC50=40000nM, Ki=5780nM
    51 5ikb:A (2.05) BS01 KAI ? GO:0015276 ... Q01812 27524200 MOAD: Kd=1.9nM
    PDBbind: -logKd/Ki=8.72, Kd=1.9nM
    BindingDB: Ki=4.7nM
    52 5mfq:A (1.9) BS03 KAI ? GO:0015276 ... P22756 28360094 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    53 5mfq:B (1.9) BS03 KAI ? GO:0015276 ... P22756 28360094 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    54 5mfv:A (2.181) BS03 KAI ? GO:0015276 ... P22756 28360094 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    55 5mfv:B (2.181) BS03 KAI ? GO:0015276 ... P22756 28360094 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    56 5mfw:A (2.1) BS02 KAI ? GO:0015276 ... P22756 28360094 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    57 5mfw:B (2.1) BS03 KAI ? GO:0015276 ... P22756 28360094 BindingDB: IC50=77nM, Ki=75.9nM, EC50=37000nM
    58 8bst:A (2.7) BS02 KAI ? GO:0015276 ... P42264 38145505
    59 8bst:B (2.7) BS03 KAI ? GO:0015276 ... P42264 38145505
    60 8bst:C (2.7) BS02 KAI ? GO:0015276 ... P42264 38145505
    61 8bst:D (2.7) BS03 KAI ? GO:0015276 ... P42264 38145505
    62 8bsu:A (2.9) BS03 KAI ? GO:0015276 ... P42264 38145505
    63 8bsu:B (2.9) BS03 KAI ? GO:0015276 ... P42264 38145505
    64 8bsu:C (2.9) BS04 KAI ? GO:0015276 ... P42264 38145505
    65 8bsu:D (2.9) BS04 KAI ? GO:0015276 ... P42264 38145505
    66 8bsu:E (2.9) BS05 KAI ? GO:0015276 ... P42264 38145505
    67 8bsu:F (2.9) BS04 KAI ? GO:0015276 ... P42264 38145505
    68 8bsu:G (2.9) BS05 KAI ? GO:0015276 ... P42264 38145505
    69 8bsu:H (2.9) BS05 KAI ? GO:0015276 ... P42264 38145505
    70 8r36:A (1.9) BS01 KAI N/A N/A P22756 39079583
    71 8r36:B (1.9) BS02 KAI N/A N/A P22756 39079583
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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