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BioLiP
Download all results in tab-seperated text for 21 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 11gs:A (2.3) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 9426214 PDBbind: -logKd/Ki=5.82, Ki=1.5uM
    BindingDB: IC50=2.6e+4nM
    2 11gs:B (2.3) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 9426214 PDBbind: -logKd/Ki=5.82, Ki=1.5uM
    BindingDB: IC50=2.6e+4nM
    3 1gse:A (2.0) BS02 EAA 1.11.1.-
    2.5.1.18
    5.3.3.-    		 GO:0004364 ... P08263 8591048 BindingDB: IC50=5000nM
    4 1gse:B (2.0) BS03 EAA 1.11.1.-
    2.5.1.18
    5.3.3.-    		 GO:0004364 ... P08263 8591048 BindingDB: IC50=5000nM
    5 1gsf:A (2.7) BS01 EAA 1.11.1.-
    2.5.1.18
    5.3.3.-    		 GO:0004364 ... P08263 8591048 PDBbind: -logKd/Ki=5.00, IC50~10uM
    BindingDB: IC50=5000nM
    6 1gsf:B (2.7) BS01 EAA 1.11.1.-
    2.5.1.18
    5.3.3.-    		 GO:0004364 ... P08263 8591048 BindingDB: IC50=5000nM
    7 1gsf:C (2.7) BS01 EAA 1.11.1.-
    2.5.1.18
    5.3.3.-    		 GO:0004364 ... P08263 8591048 BindingDB: IC50=5000nM
    8 1gsf:D (2.7) BS01 EAA 1.11.1.-
    2.5.1.18
    5.3.3.-    		 GO:0004364 ... P08263 8591048 BindingDB: IC50=5000nM
    9 2gss:A (1.9) BS01 EAA 2.5.1.18 GO:0000302 ... P09211 9012673 MOAD: Ki=11.5uM
    PDBbind: -logKd/Ki=4.94, Ki=11.5uM
    BindingDB: IC50=2.6e+4nM
    10 2gss:B (1.9) BS01 EAA 2.5.1.18 GO:0000302 ... P09211 9012673 MOAD: Ki=11.5uM
    PDBbind: -logKd/Ki=4.94, Ki=11.5uM
    BindingDB: IC50=2.6e+4nM
    11 3dgq:A (1.6) BS01 EAA 2.5.1.18 GO:0000302 ... P09211 19396894 MOAD: ic50=12uM
    PDBbind: -logKd/Ki=4.92, IC50=12.0uM
    BindingDB: IC50=2.6e+4nM
    12 3gss:A (1.9) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 9012673 PDBbind: -logKd/Ki=5.82, Ki=1.5uM
    BindingDB: IC50=2.6e+4nM
    13 3gss:B (1.9) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 9012673 PDBbind: -logKd/Ki=5.82, Ki=1.5uM
    BindingDB: IC50=2.6e+4nM
    14 3hjo:A (1.95) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 19780048 PDBbind: -logKd/Ki=6.52, Kd=0.3uM
    BindingDB: IC50=2.6e+4nM
    15 3hjo:B (1.95) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 19780048 BindingDB: IC50=2.6e+4nM
    16 3km6:A (2.1) BS01 EAA 2.5.1.18 GO:0000302 ... P09211 20540076 BindingDB: IC50=2.6e+4nM
    17 3km6:B (2.1) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 20540076 BindingDB: IC50=2.6e+4nM
    18 3kmo:A (2.6) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 N/A BindingDB: IC50=2.6e+4nM
    19 3kmo:B (2.6) BS03 EAA 2.5.1.18 GO:0000302 ... P09211 N/A BindingDB: IC50=2.6e+4nM
    20 3n9j:A (1.85) BS01 EAA 2.5.1.18 GO:0000302 ... P09211 N/A BindingDB: IC50=2.6e+4nM
    21 3n9j:B (1.85) BS02 EAA 2.5.1.18 GO:0000302 ... P09211 N/A BindingDB: IC50=2.6e+4nM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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