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BioLiP
Download all results in tab-seperated text for 50 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1dvx:A (2.0) BS01 DIF ? GO:0005179 ... P02766 10742177 BindingDB: Kd=1000nM, IC50=140000nM
    2 1nr6:A (2.1) BS02 DIF 1.14.14.1 GO:0004497 ... P00179 12899620 MOAD: Kd~50uM
    3 1pxx:A (2.9) BS02 DIF 1.14.99.1 GO:0004601 ... Q05769 12925531 BindingDB: IC50=22nM
    4 1pxx:B (2.9) BS02 DIF 1.14.99.1 GO:0004601 ... Q05769 12925531 BindingDB: IC50=22nM
    5 1pxx:C (2.9) BS02 DIF 1.14.99.1 GO:0004601 ... Q05769 12925531 BindingDB: IC50=22nM
    6 1pxx:D (2.9) BS02 DIF 1.14.99.1 GO:0004601 ... Q05769 12925531 BindingDB: IC50=22nM
    7 1sv9:A (2.71) BS01 DIF 3.1.1.4 GO:0004623 ... P59071 N/A
    8 2b17:A (2.71) BS01 DIF 3.1.1.4 GO:0004623 ... P59071 16552142 PDBbind: -logKd/Ki=6.21, Ki=0.62uM
    9 2wek:A (1.9) BS02 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    10 2wek:A (1.9) BS03 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    11 2wek:A (1.9) BS04 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    12 2wek:A (1.9) BS05 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    13 2wek:B (1.9) BS02 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    14 2wek:B (1.9) BS03 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    15 2wek:B (1.9) BS04 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    16 2wek:B (1.9) BS05 DIF 1.3.1.48 GO:0003674 ... Q8N4Q0 N/A
    17 3cfq:A (2.09) BS01 DIF ? GO:0005179 ... P02766 19954984 BindingDB: Kd=1000nM, IC50=140000nM
    18 3cfq:B (2.09) BS01 DIF ? GO:0005179 ... P02766 19954984 BindingDB: Kd=1000nM, IC50=140000nM
    19 3ib0:A (1.4) BS03 DIF 3.4.21.- GO:0005576 ... P24627 20006955
    20 3n8y:A (2.6) BS02 DIF 1.14.99.1 GO:0001516 ... P05979 20669977 BindingDB: IC50=70nM
    21 3n8y:B (2.6) BS02 DIF 1.14.99.1 GO:0001516 ... P05979 20669977 BindingDB: IC50=70nM
    22 4oj4:A (2.3) BS01 DIF ? GO:0003677 ... P37231 N/A
    23 4ubs:A (2.2) BS02 DIF 1.14.15.11 GO:0004497 ... Q825I8 25341403 MOAD: Kd=65uM
    24 4ubs:A (2.2) BS03 DIF 1.14.15.11 GO:0004497 ... Q825I8 25341403 MOAD: Kd=65uM
    25 4xta:A (2.5) BS01 DIF ? GO:0003677 ... P37231 26445566 MOAD: ic50=3.7uM
    PDBbind: -logKd/Ki=5.43, IC50=3.7uM
    26 4xta:B (2.5) BS01 DIF ? GO:0003677 ... P37231 26445566 MOAD: ic50=3.7uM
    27 4z69:A (2.187) BS06 DIF ? GO:0003677 ... P02768 25958880 BindingDB: Kd=2455nM, Ki=99999999999999nM
    28 4z69:A (2.187) BS07 DIF ? GO:0003677 ... P02768 25958880 BindingDB: Kd=2455nM, Ki=99999999999999nM
    29 4z69:A (2.187) BS08 DIF ? GO:0003677 ... P02768 25958880 BindingDB: Kd=2455nM, Ki=99999999999999nM
    30 4z69:I (2.187) BS06 DIF ? GO:0003677 ... P02768 25958880 BindingDB: Kd=2455nM, Ki=99999999999999nM
    31 4zbq:A (1.92) BS01 DIF ? GO:0003677 ... P35747 26652101 MOAD: Ka=39000M^-1
    32 4zbq:A (1.92) BS02 DIF ? GO:0003677 ... P35747 26652101 MOAD: Ka=39000M^-1
    33 4zbr:A (2.19) BS01 DIF ? GO:0003677 ... P35747 26652101 MOAD: Ka=39000M^-1
    34 5dby:A (2.35) BS01 DIF ? GO:0003677 ... P35747 26652101 MOAD: Ka=39000M^-1
    35 5u1r:A (2.7) BS01 DIF ? N/A Q95460 28166217
    36 5u1r:C (2.7) BS01 DIF ? N/A Q95460 28166217
    37 6hn0:A (2.12) BS01 DIF ? GO:0005576 ... P14639 36675044
    38 6hn0:A (2.12) BS02 DIF ? GO:0005576 ... P14639 36675044
    39 6hn0:A (2.12) BS03 DIF ? GO:0005576 ... P14639 36675044
    40 6hn0:A (2.12) BS04 DIF ? GO:0005576 ... P14639 36675044
    41 6hn0:A (2.12) BS05 DIF ? GO:0005576 ... P14639 36675044
    42 6hn0:A (2.12) BS06 DIF ? GO:0005576 ... P14639 36675044
    43 6hn1:A (1.55) BS01 DIF ? GO:0005576 ... A0A452F7K4 36675044
    44 6hn1:A (1.55) BS02 DIF ? GO:0005576 ... A0A452F7K4 36675044
    45 6hn1:A (1.55) BS03 DIF ? GO:0005576 ... A0A452F7K4 36675044
    46 6hn1:A (1.55) BS04 DIF ? GO:0005576 ... A0A452F7K4 36675044
    47 6hn1:A (1.55) BS05 DIF ? GO:0005576 ... A0A452F7K4 36675044
    48 6hn1:A (1.55) BS06 DIF ? GO:0005576 ... A0A452F7K4 36675044
    49 8bsg:A (1.89) BS01 DIF ? GO:0003677 ... P49065 36675044
    50 8bsg:A (1.89) BS02 DIF ? GO:0003677 ... P49065 36675044
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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