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BioLiP Library
Download all results in tab-seperated text for 13 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1eqc:A (1.85) BS01 CTS 2.4.1.-
    3.2.1.58    		 GO:0000272 ... P29717 10610795
    2 2cbu:A (1.85) BS01 CTS 3.2.1.21 GO:0004553 ... Q08638 16628756 MOAD: Kd=2.1uM
    PDBbind: -logKd/Ki=5.68, Kd=2.1uM
    3 2cbu:B (1.85) BS01 CTS 3.2.1.21 GO:0004553 ... Q08638 16628756 MOAD: Kd=2.1uM
    4 2jkp:A (1.99) BS01 CTS 3.2.1.3 GO:0000272 ... G8JZS4 18848471 MOAD: Ki=59uM
    PDBbind: -logKd/Ki=4.23, Ki=59uM
    5 2jkp:B (1.99) BS01 CTS 3.2.1.3 GO:0000272 ... G8JZS4 18848471 MOAD: Ki=59uM
    6 2pwg:A (2.2) BS02 CTS 5.4.99.11 GO:0004556 ... Q2PS28 17597061 MOAD: Ki=15uM
    PDBbind: -logKd/Ki=4.82, Ki=15uM
    7 2pwg:B (2.2) BS02 CTS 5.4.99.11 GO:0004556 ... Q2PS28 17597061 MOAD: Ki=15uM
    8 2vl8:A (2.31) BS02 CTS 2.4.1.-
    3.4.22.-    		 GO:0016757 ... Q46342 18505687 MOAD: ic50~30uM
    9 2vl8:B (2.31) BS02 CTS 2.4.1.-
    3.4.22.-    		 GO:0016757 ... Q46342 18505687 MOAD: ic50~30uM
    10 2vl8:C (2.31) BS02 CTS 2.4.1.-
    3.4.22.-    		 GO:0016757 ... Q46342 18505687 MOAD: ic50~30uM
    11 4iif:A (2.45) BS05 CTS 3.2.1.21 GO:0004553 ... P48825 23537284 MOAD: Ki=6.6uM
    PDBbind: -logKd/Ki=5.18, Ki=6.6uM
    12 4iif:B (2.45) BS07 CTS 3.2.1.21 GO:0004553 ... P48825 23537284 MOAD: Ki=6.6uM
    13 5ied:A (1.81) BS01 CTS 3.2.1.207 GO:0003824 ... Q8BHN3 27462106
    Reference:
    • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
    • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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