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BioLiP
Download all results in tab-seperated text for 77 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1gw6:A (2.2) BS01 BES 3.3.2.6
    3.4.11.4    		 GO:0003723 ... P09960 11917124 BindingDB: IC50=4000nM, Kd=2050nM, Ki=320nM
    2 1hs6:A (1.95) BS02 BES 3.3.2.6
    3.4.11.4    		 GO:0003723 ... P09960 11175901 PDBbind: -logKd/Ki=5.38, IC50=4.2uM
    BindingDB: IC50=4000nM, Kd=2050nM, Ki=320nM
    3 1txr:A (2.0) BS03 BES 3.4.11.10 GO:0006508 ... Q01693 15274616 MOAD: Ki=18nM
    PDBbind: -logKd/Ki=7.74, Ki=18nM
    BindingDB: IC50=1.6nM, Ki=1.6nM
    4 1xry:A (2.1) BS03 BES 3.4.11.10 GO:0006508 ... Q01693 N/A BindingDB: IC50=1.6nM, Ki=1.6nM
    5 2dqm:A (1.6) BS02 BES 3.4.11.2 GO:0004177 ... P04825 16885166
    6 2ek9:A (1.97) BS05 BES ? GO:0004177 ... A2V759 N/A
    7 2hpt:A (2.3) BS02 BES 3.4.11.2 GO:0004177 ... P04825 16938892
    8 2xq0:A (1.955) BS01 BES 3.3.2.10
    3.4.11.-    		 GO:0004177 ... Q10740 21146536
    9 2yd0:A (2.7) BS02 BES 3.4.11.- GO:0001525 ... Q9NZ08 21508329 BindingDB: IC50=50000nM
    10 2zof:A (2.3) BS03 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540 MOAD: ic50=7nM
    PDBbind: -logKd/Ki=8.15, IC50=7nM
    11 2zof:A (2.3) BS04 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540 MOAD: ic50=7nM
    PDBbind: -logKd/Ki=8.15, IC50=7nM
    12 2zof:B (2.3) BS01 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540 MOAD: ic50=7nM
    PDBbind: -logKd/Ki=8.15, IC50=7nM
    13 2zof:B (2.3) BS04 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540 MOAD: ic50=7nM
    PDBbind: -logKd/Ki=8.15, IC50=7nM
    14 2zog:A (1.7) BS03 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540
    15 2zog:A (1.7) BS04 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540
    16 2zog:B (1.7) BS01 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540
    17 2zog:B (1.7) BS04 BES 3.4.13.18 GO:0004180 ... Q9D1A2 18550540
    18 3ebh:A (1.65) BS02 BES 3.4.11.- GO:0006508 ... O96935 19196988 MOAD: Ki=478.2nM
    PDBbind: -logKd/Ki=6.32, Ki=478.2nM
    BindingDB: Ki=190nM, IC50=284nM
    19 3ftx:A (1.96) BS03 BES 3.3.2.6
    3.4.11.4    		 GO:0003723 ... P09960 19618939 BindingDB: IC50=4000nM, Kd=2050nM, Ki=320nM
    20 3fue:A (2.38) BS03 BES 3.3.2.6
    3.4.11.4    		 GO:0003723 ... P09960 19618939 BindingDB: IC50=4000nM, Kd=2050nM, Ki=320nM
    21 3fuf:A (2.6) BS03 BES 3.3.2.6
    3.4.11.4    		 GO:0003723 ... P09960 19618939 BindingDB: IC50=4000nM, Kd=2050nM, Ki=320nM
    22 3fuh:A (1.8) BS03 BES 3.3.2.6
    3.4.11.4    		 GO:0003723 ... P09960 19618939 BindingDB: IC50=4000nM, Kd=2050nM, Ki=320nM
    23 3h8g:A (1.5) BS04 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O86436 20359484
    24 3h8g:B (1.5) BS04 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O86436 20359484
    25 3h8g:C (1.5) BS04 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O86436 20359484
    26 3h8g:D (1.5) BS04 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O86436 20359484
    27 3h8g:E (1.5) BS04 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O86436 20359484
    28 3h8g:F (1.5) BS04 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O86436 20359484
    29 3kr4:A (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    PDBbind: -logKd/Ki=7.60, Ki=25nM
    30 3kr4:B (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    31 3kr4:C (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    32 3kr4:D (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    33 3kr4:E (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    34 3kr4:F (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    PDBbind: -logKd/Ki=7.60, Ki=25nM
    35 3kr4:G (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    36 3kr4:H (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    37 3kr4:I (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    38 3kr4:J (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    39 3kr4:K (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    40 3kr4:L (2.0) BS03 BES 3.4.11.1
    3.4.13.-    		 GO:0005737 ... Q8IL11 20133789 MOAD: Ki=25nM
    41 3mdj:A (2.95) BS02 BES 3.4.11.- GO:0001525 ... Q9NZ08 21478864 BindingDB: IC50=50000nM
    42 3mdj:B (2.95) BS02 BES 3.4.11.- GO:0001525 ... Q9NZ08 21478864 BindingDB: IC50=50000nM
    43 3mdj:C (2.95) BS02 BES 3.4.11.- GO:0001525 ... Q9NZ08 21478864 BindingDB: IC50=50000nM
    44 4fkk:A (2.6) BS01 BES 3.4.11.2 GO:0001525 ... P15145 23071329 PDBbind: -logKd/Ki=9.30, Ki=0.5nM
    BindingDB: Ki=4100nM, IC50=9400nM
    45 4fyr:A (1.91) BS02 BES 3.4.11.2 GO:0001525 ... P15144 22932899 BindingDB: IC50=20120nM, Ki=2370nM
    46 4gaa:A (2.26) BS02 BES 3.3.2.6
    3.4.11.4    		 GO:0004177 ... Q6IP81 24333438
    47 4gaa:B (2.26) BS02 BES 3.3.2.6
    3.4.11.4    		 GO:0004177 ... Q6IP81 24333438
    48 4kxb:A (2.4) BS02 BES 3.4.11.7 GO:0001525 ... Q07075 23888046 PDBbind: -logKd/Ki=4.12, Ki=75uM
    49 4ruh:A (2.25) BS01 BES 3.4.13.18 GO:0004180 ... Q96KP4 N/A
    50 4ruh:A (2.25) BS04 BES 3.4.13.18 GO:0004180 ... Q96KP4 N/A
    51 4ruh:B (2.25) BS01 BES 3.4.13.18 GO:0004180 ... Q96KP4 N/A
    52 4ruh:B (2.25) BS02 BES 3.4.13.18 GO:0004180 ... Q96KP4 N/A
    53 4xmx:A (2.3) BS02 BES 3.4.11.2 GO:0004177 ... P04825 N/A
    54 4zla:A (1.9) BS05 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O25294 26616008 MOAD: ic50=49.9nM
    PDBbind: -logKd/Ki=7.30, IC50=49.9nM
    55 4zla:B (1.9) BS05 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O25294 26616008 MOAD: ic50=49.9nM
    PDBbind: -logKd/Ki=7.30, IC50=49.9nM
    56 4zla:C (1.9) BS05 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O25294 26616008 MOAD: ic50=49.9nM
    57 4zla:D (1.9) BS05 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O25294 26616008 MOAD: ic50=49.9nM
    58 4zla:E (1.9) BS05 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O25294 26616008 MOAD: ic50=49.9nM
    PDBbind: -logKd/Ki=7.30, IC50=49.9nM
    59 4zla:F (1.9) BS05 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... O25294 26616008 MOAD: ic50=49.9nM
    60 5ib9:A (1.4) BS05 BES ? GO:0004177 ... A2V759 N/A
    61 5ntd:A (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    62 5ntd:B (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    63 5ntd:C (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    64 5ntd:D (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    65 5ntd:E (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    66 5ntd:F (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    67 5ntd:G (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    68 5ntd:H (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    69 5ntd:I (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    70 5ntd:J (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    71 5ntd:K (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    72 5ntd:L (2.3) BS03 BES ? GO:0004177 ... Q385B0 28815215
    73 8j9d:A (1.9) BS02 BES ? N/A B0RY21 38646733
    74 8j9d:B (1.9) BS02 BES ? N/A B0RY21 38646733
    75 8j9d:C (1.9) BS02 BES ? N/A B0RY21 38646733
    76 8j9d:D (1.9) BS02 BES ? N/A B0RY21 38646733
    77 8pzm:A (1.7) BS01 BES 3.4.11.1
    3.4.11.10    		 GO:0004177 ... Q02RY8 37924287
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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