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BioLiP
Download all results in tab-seperated text for 12 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1kv2:A (2.8) BS01 B96 2.7.11.24 GO:0000077 ... Q16539 11896401 PDBbind: -logKd/Ki=10.00, Kd=0.1nM
    BindingDB: Kd=0.1nM, IC50=12nM, Ki=22nM, koff=0.000008s-1, kon=84900M-1-s-1
    2 3fzs:A (1.75) BS01 B96 2.7.10.2 GO:0004672 ... Q14289 19244237 MOAD: ic50=1.5uM
    PDBbind: -logKd/Ki=5.82, IC50=1.5uM
    BindingDB: Kd=990nM, IC50=400nM
    3 3npc:A (2.35) BS01 B96 2.7.11.24 GO:0004672 ... P45984 20655210 PDBbind: -logKd/Ki=8.34, Kd=4.6nM
    BindingDB: Kd=7.3nM, IC50=6nM
    4 3npc:B (2.35) BS01 B96 2.7.11.24 GO:0004672 ... P45984 20655210 BindingDB: Kd=7.3nM, IC50=6nM
    5 4jvg:A (3.09) BS01 B96 2.7.11.1 GO:0004672 ... P15056 23685672 BindingDB: Kd=2700nM, IC50=83.4nM
    6 4jvg:B (3.09) BS01 B96 2.7.11.1 GO:0004672 ... P15056 23685672 BindingDB: Kd=2700nM, IC50=83.4nM
    7 4jvg:C (3.09) BS01 B96 2.7.11.1 GO:0004672 ... P15056 23685672 BindingDB: Kd=2700nM, IC50=83.4nM
    8 4jvg:D (3.09) BS01 B96 2.7.11.1 GO:0004672 ... P15056 23685672 BindingDB: Kd=2700nM, IC50=83.4nM
    9 4twn:A (1.706) BS01 B96 2.7.10.1 GO:0004672 ... P29320 25589935 BindingDB: Kd=880nM, IC50=<1000nM
    10 5n66:A (2.4) BS02 B96 2.7.11.24 GO:0000077 ... Q16539 28892510 BindingDB: Kd=0.1nM, IC50=12nM, Ki=22nM, koff=0.000008s-1, kon=84900M-1-s-1
    11 6gtt:A (2.25) BS01 B96 2.7.11.1 GO:0004672 ... O94804 N/A BindingDB: Kd=12nM, IC50=<1000nM
    12 8ygw:A (3.301) BS01 B96 2.7.11.24 GO:0000165 ... Q15759 N/A
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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