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BioLiP
Download all results in tab-seperated text for 15 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1h1s:A (2.0) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: Ki=6nM
    PDBbind: -logKd/Ki=8.22, Ki=6nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    2 1h1s:C (2.0) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 12244298 MOAD: Ki=6nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    3 2c6o:A (2.1) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 16325401 PDBbind: -logKd/Ki=8.22, Ki=6nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    4 2iw8:A (2.3) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 16942020 MOAD: ic50=103nM
    PDBbind: -logKd/Ki=6.99, IC50=103nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    5 2iw8:C (2.3) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 16942020 MOAD: ic50=103nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    6 2iw9:A (2.0) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 16942020 MOAD: ic50=8.9nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    7 2iw9:C (2.0) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 16942020 MOAD: ic50=8.9nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    8 4eok:A (2.57) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 22921070 PDBbind: -logKd/Ki=5.07, Ki=8600nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    9 4eok:C (2.57) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 22921070 BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    10 4eor:A (2.2) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 22921070 MOAD: Ki=500nM
    PDBbind: -logKd/Ki=6.30, Ki=500nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    11 4eor:C (2.2) BS01 4SP 2.7.11.22 GO:0000082 ... P24941 22921070 MOAD: Ki=500nM
    BindingDB: IC50=6.0nM, Ki=6.0nM, Kd=1310nM
    12 5lqf:A (2.06) BS01 4SP 2.7.11.22
    2.7.11.23    		 GO:0000082 ... P06493 28005359 PDBbind: -logKd/Ki=6.60, IC50=0.25uM
    BindingDB: IC50=250nM
    13 5lqf:D (2.06) BS01 4SP 2.7.11.22
    2.7.11.23    		 GO:0000082 ... P06493 28005359 BindingDB: IC50=250nM
    14 5m57:A (2.3) BS01 4SP 2.7.11.1 GO:0004672 ... P51955 27833088 MOAD: ic50=12uM
    PDBbind: -logKd/Ki=4.92, IC50=12uM
    15 6bss:A (2.1) BS01 4SP 2.7.10.2 GO:0004672 ... O60674 N/A
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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