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BioLiP
Download all results in tab-seperated text for 55 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1fej:C (1.78) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    2 1fej:D (1.78) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    3 1ff0:C (1.85) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    4 1ff0:D (1.85) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    5 1ffi:C (1.7) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    6 1ffi:D (1.7) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    7 1fg6:C (1.8) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    8 1fg6:D (1.8) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    9 1fgc:C (1.9) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    10 1fgc:D (1.9) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 11340661
    11 2aoc:A (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16218957 PDBbind: -logKd/Ki=4.89, Ki=13.0uM
    12 2aoc:B (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16218957 PDBbind: -logKd/Ki=4.89, Ki=13.0uM
    13 2aod:A (1.4) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16218957 PDBbind: -logKd/Ki=5.66, Ki=2.17uM
    14 2aod:B (1.4) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16218957 PDBbind: -logKd/Ki=5.66, Ki=2.17uM
    15 2aog:A (1.1) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16218957 MOAD: Ki=0.53uM
    PDBbind: -logKd/Ki=6.28, Ki=0.53uM
    16 2aog:B (1.1) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16218957 PDBbind: -logKd/Ki=6.28, Ki=0.53uM
    17 2avm:A (1.1) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 PDBbind: -logKd/Ki=5.70, Ki=2.0uM
    18 2avm:B (1.1) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 MOAD: Ki=2uM
    PDBbind: -logKd/Ki=5.70, Ki=2.0uM
    19 2avq:A (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 PDBbind: -logKd/Ki=4.39, Ki=41uM
    20 2avq:B (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 MOAD: Ki=41uM
    PDBbind: -logKd/Ki=4.39, Ki=41uM
    21 2j9k:A (1.2) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 17869270
    22 2j9k:B (1.2) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 17869270
    23 2o40:A (1.65) BS01 2NC 3.4.23.16 GO:0004190 ... O38716 17397076
    24 3bva:A (1.05) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 18281688 PDBbind: -logKd/Ki=6.52, Kd=0.30uM
    25 3bva:B (1.05) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 18281688 MOAD: Ka=3300000M^-1
    PDBbind: -logKd/Ki=6.52, Kd=0.30uM
    26 3fsm:A (1.6) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=100nM
    PDBbind: -logKd/Ki=7.00, Kd=0.1uM
    27 3hau:A (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=0.42uM
    PDBbind: -logKd/Ki=6.38, Kd=0.42uM
    28 3hau:B (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    29 3haw:A (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    30 3haw:B (1.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=1.01uM
    PDBbind: -logKd/Ki=6.00, Kd=1.01uM
    31 3hbo:A (1.71) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=8.2uM
    PDBbind: -logKd/Ki=5.09, Kd=8.2uM
    32 3hbo:B (1.71) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    33 3hdk:A (1.8) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    34 3hdk:B (1.8) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=17.5uM
    PDBbind: -logKd/Ki=4.76, Kd=17.5uM
    35 3hlo:A (1.6) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=0.61uM
    PDBbind: -logKd/Ki=6.21, Kd=0.61uM
    36 3hzc:A (1.45) BS01 2NC 3.4.23.16 GO:0004190 ... O38732 N/A
    37 3i2l:A (1.5) BS01 2NC 3.4.23.16 GO:0004190 ... O38732 N/A
    38 3i2l:B (1.5) BS01 2NC 3.4.23.16 GO:0004190 ... O38732 N/A
    39 3ia9:A (1.3) BS01 2NC 3.4.23.16 GO:0004190 ... O38732 N/A
    40 3ia9:B (1.3) BS01 2NC 3.4.23.16 GO:0004190 ... O38732 N/A
    41 3iaw:A (1.61) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=1.57uM
    PDBbind: -logKd/Ki=5.80, Kd=1.57uM
    42 3ka2:A (1.4) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985 MOAD: Kd=0.24uM
    PDBbind: -logKd/Ki=6.62, Kd=0.24uM
    43 3nwq:A (1.5) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    44 3nwq:B (1.5) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    45 3nxe:A (1.61) BS01 2NC 3.4.23.16 GO:0004190 ... O38716 22158985
    46 3nyg:A (1.45) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    47 3nyg:B (1.45) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 22158985
    48 3uhl:C (2.2) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 22404139
    49 3uhl:D (2.2) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 22404139
    50 4hvp:A (2.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 2686029
    51 4hvp:B (2.3) BS01 2NC 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 2686029 MOAD: Ki=0.78uM
    52 6o57:A (1.71) BS01 2NC ? GO:0004190 ... I7BFC3 31172041
    53 6o57:B (1.71) BS01 2NC ? GO:0004190 ... I7BFC3 31172041 MOAD: Ki=514nM
    54 6o5a:A (1.67) BS01 2NC ? GO:0004190 ... I7BFC3 31172041 MOAD: Ki=514nM
    55 6o5a:B (1.67) BS01 2NC ? GO:0004190 ... I7BFC3 31172041
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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