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BioLiP
Download all results in tab-seperated text for 17 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2ohk:A (2.2) BS01 1SQ 3.4.23.46 GO:0004190 ... P56817 17315856 PDBbind: -logKd/Ki=2.70, IC50~2000uM
    BindingDB: IC50=2000000nM
    2 3kpw:A (2.4) BS02 1SQ 2.1.1.28 GO:0004603 ... P11086 20642456 MOAD: Kd=14uM
    PDBbind: -logKd/Ki=4.85, Kd=14uM
    3 3kpw:B (2.4) BS02 1SQ 2.1.1.28 GO:0004603 ... P11086 20642456 MOAD: Kd=14uM
    4 4yuy:A (1.58) BS02 1SQ 2.5.1.16 GO:0003824 ... Q4DA73 26327378 MOAD: ic50=460uM
    PDBbind: -logKd/Ki=3.34, IC50=460uM
    5 4yuy:B (1.58) BS02 1SQ 2.5.1.16 GO:0003824 ... Q4DA73 26327378 MOAD: ic50=460uM
    6 5aqs:A (2.0) BS01 1SQ 3.6.4.10 GO:0005524 ... P11142 27708405
    7 5aqs:C (2.0) BS01 1SQ 3.6.4.10 GO:0005524 ... P11142 27708405
    8 5ru8:A (1.0) BS01 1SQ 2.1.1.56
    2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.4.22.69
    3.6.4.12
    3.6.4.13
    4.6.1.-    		 N/A P0DTD1 33853786
    9 5rvp:A (1.04) BS01 1SQ 2.1.1.56
    2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.4.22.69
    3.6.4.12
    3.6.4.13
    4.6.1.-    		 N/A P0DTD1 33853786
    10 7axw:A (1.69) BS02 1SQ 2.7.11.11 GO:0000287 ... P25321 N/A
    11 7h9g:A (1.53) BS01 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    12 7h9g:A (1.53) BS02 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    13 7h9g:B (1.53) BS01 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    14 7h9g:C (1.53) BS01 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    15 7h9g:C (1.53) BS02 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    16 7h9g:D (1.53) BS01 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    17 7h9g:D (1.53) BS02 1SQ 2.1.1.-
    2.7.7.-
    2.7.7.19
    2.7.7.48
    3.1.3.84
    3.4.22.-
    3.6.1.15
    3.6.1.74
    3.6.4.13    		 N/A Q8JUX6 N/A
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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