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BioLiP
Download all results in tab-seperated text for 594392 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    192001 4yy1:A (3.1) BS02 SIA ? GO:0005886 ... A0A0J9X268 N/A
    192002 4yy1:C (3.1) BS01 SIA ? GO:0005886 ... A0A0J9X268 N/A
    192003 4yy3:B (3.6) BS01 rna ? GO:0003735 ... P80371 27307497
    192004 4yy3:B (3.6) BS02 MG ? GO:0003735 ... P80371 27307497
    192005 4yy3:C (3.6) BS01 rna ? GO:0003676 ... P80372 27307497
    192006 4yy3:D (3.6) BS01 rna ? GO:0003723 ... P80373 27307497
    192007 4yy3:E (3.6) BS01 rna ? GO:0003723 ... Q5SHQ5 27307497
    192008 4yy3:F (3.6) BS01 rna ? GO:0003735 ... Q5SLP8 27307497
    192009 4yy3:G (3.6) BS01 rna ? GO:0000028 ... P17291 27307497
    192010 4yy3:H (3.6) BS01 rna ? GO:0003735 ... P0DOY9 27307497
    192011 4yy3:I (3.6) BS01 rna ? GO:0000049 ... P80374 27307497
    192012 4yy3:J (3.6) BS01 rna ? GO:0000049 ... Q5SHN7 27307497
    192013 4yy3:K (3.6) BS01 rna ? GO:0003735 ... P80376 27307497
    192014 4yy3:L (3.6) BS01 rna ? GO:0000049 ... Q5SHN3 27307497
    192015 4yy3:M (3.6) BS01 rna ? GO:0000049 ... P80377 27307497
    192016 4yy3:N (3.6) BS01 rna ? GO:0003735 ... P0DOY6 27307497
    192017 4yy3:N (3.6) BS02 ZN ? GO:0003735 ... P0DOY6 27307497
    192018 4yy3:O (3.6) BS01 rna ? GO:0003735 ... Q5SJ76 27307497
    192019 4yy3:P (3.6) BS01 rna ? GO:0003735 ... Q5SJH3 27307497
    192020 4yy3:Q (3.6) BS01 rna ? GO:0003735 ... P0DOY7 27307497
    192021 4yy3:R (3.6) BS01 rna ? GO:0003735 ... Q5SLQ0 27307497
    192022 4yy3:S (3.6) BS01 rna ? GO:0000028 ... Q5SHP2 27307497
    192023 4yy3:T (3.6) BS01 rna ? GO:0003723 ... P80380 27307497
    192024 4yy7:A (2.99) BS01 GAL ? GO:0005886 ... A0A0J9X268 N/A
    192025 4yy7:A (2.99) BS02 SIA ? GO:0005886 ... A0A0J9X268 N/A
    192026 4yy7:C (2.99) BS01 GAL ? GO:0005886 ... A0A0J9X268 N/A
    192027 4yy7:C (2.99) BS02 SIA ? GO:0005886 ... A0A0J9X268 N/A
    192028 4yya:A (2.595) BS01 SIA ? GO:0005886 ... A0A0J9X268 N/A
    192029 4yyb:A (2.609) BS01 GAL ? GO:0005886 ... A0A0J9X268 N/A
    192030 4yyb:A (2.609) BS02 SIA ? GO:0005886 ... A0A0J9X268 N/A
    192031 4yye:A (2.301) BS01 rna 6.1.1.3 GO:0000166 ... P07236 26704982
    192032 4yye:A (2.301) BS02 rna 6.1.1.3 GO:0000166 ... P07236 26704982
    192033 4yye:A (2.301) BS03 ZN 6.1.1.3 GO:0000166 ... P07236 26704982
    192034 4yye:A (2.301) BS04 TSB 6.1.1.3 GO:0000166 ... P07236 26704982
    192035 4yye:B (2.301) BS01 rna 6.1.1.3 GO:0000166 ... P07236 26704982
    192036 4yye:B (2.301) BS02 rna 6.1.1.3 GO:0000166 ... P07236 26704982
    192037 4yye:B (2.301) BS03 ZN 6.1.1.3 GO:0000166 ... P07236 26704982
    192038 4yye:B (2.301) BS04 TSB 6.1.1.3 GO:0000166 ... P07236 26704982
    192039 4yym:A (1.5) BS01 peptide 2.3.1.48
    2.7.11.1    		 GO:0004402 ... P21675 26365797
    192040 4yym:B (1.5) BS01 peptide 2.3.1.48
    2.7.11.1    		 GO:0004402 ... P21675 26365797
    192041 4yyn:A (1.85) BS01 peptide 2.3.1.48
    2.7.11.1    		 GO:0004402 ... P21675 26365797
    192042 4yyn:B (1.85) BS01 peptide 2.3.1.48
    2.7.11.1    		 GO:0004402 ... P21675 26365797
    192043 4yyo:A (1.77) BS01 FE2 1.13.11.20 GO:0005506 ... P21816 27193596
    192044 4yyt:A (1.07) BS01 S2O 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 26700575 MOAD: Kd=418.3nM
    PDBbind: -logKd/Ki=6.38, Kd=418.3nM
    BindingDB: Ki=125nM, IC50=3000nM, Kd=392000nM
    192045 4yyt:A (1.07) BS02 S2O 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 26700575 MOAD: Kd=418.3nM
    PDBbind: -logKd/Ki=6.38, Kd=418.3nM
    BindingDB: Ki=125nM, IC50=3000nM, Kd=392000nM
    192046 4yyt:A (1.07) BS03 S2O 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 26700575 MOAD: Kd=418.3nM
    PDBbind: -logKd/Ki=6.38, Kd=418.3nM
    BindingDB: Ki=125nM, IC50=3000nM, Kd=392000nM
    192047 4yyt:A (1.07) BS04 S2O 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 26700575 MOAD: Kd=418.3nM
    PDBbind: -logKd/Ki=6.38, Kd=418.3nM
    BindingDB: Ki=125nM, IC50=3000nM, Kd=392000nM
    192048 4yyt:A (1.07) BS05 ZN 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 26700575
    192049 4yyy:B (2.43) BS01 URI 2.4.2.4 GO:0004645 ... Q7CP66 26919527
    192050 4yyy:B (2.43) BS02 URI 2.4.2.4 GO:0004645 ... Q7CP66 26919527
    192051 4yz0:A (1.15) BS01 X1X 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192052 4yz0:A (1.15) BS02 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192053 4yz0:A (1.15) BS03 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192054 4yz0:A (1.15) BS04 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192055 4yz0:A (1.15) BS05 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192056 4yz0:A (1.15) BS06 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192057 4yz0:A (1.15) BS07 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192058 4yz0:A (1.15) BS08 GTR 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192059 4yz0:A (1.15) BS09 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192060 4yz0:A (1.15) BS10 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192061 4yz0:B (1.15) BS01 X0X 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192062 4yz0:B (1.15) BS02 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192063 4yz0:B (1.15) BS03 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192064 4yz0:B (1.15) BS04 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192065 4yz0:B (1.15) BS05 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192066 4yz0:B (1.15) BS06 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192067 4yz0:B (1.15) BS07 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192068 4yz0:B (1.15) BS08 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192069 4yz0:B (1.15) BS09 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192070 4yz0:B (1.15) BS10 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192071 4yz0:B (1.15) BS11 GTR 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192072 4yz0:B (1.15) BS12 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192073 4yz0:B (1.15) BS13 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192074 4yz2:A (2.06) BS01 DAN 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192075 4yz2:B (2.06) BS01 DAN 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192076 4yz3:A (2.38) BS01 G39 3.2.1.18 GO:0004308 ... A0A0H2UQE4 N/A
    192077 4yz3:B (2.38) BS01 G39 3.2.1.18 GO:0004308 ... A0A0H2UQE4 N/A
    192078 4yz4:A (2.15) BS01 SIA 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192079 4yz4:B (2.15) BS01 SIA 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192080 4yz5:A (2.27) BS01 SIA 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192081 4yz5:A (2.27) BS02 DAN 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192082 4yz5:B (2.27) BS01 SIA 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192083 4yz5:B (2.27) BS02 DAN 3.2.1.18 GO:0004308 ... A0A0H2UQE4 26370075
    192084 4yz7:A (1.9589) BS01 9AR ? GO:0004623 ... P58399 26192963
    192085 4yz7:B (1.9589) BS01 9AR ? GO:0004623 ... P58399 26192963
    192086 4yza:A (1.25) BS01 X1X 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192087 4yza:A (1.25) BS02 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192088 4yza:A (1.25) BS03 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192089 4yza:A (1.25) BS04 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192090 4yza:A (1.25) BS05 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192091 4yza:A (1.25) BS06 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192092 4yza:A (1.25) BS07 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192093 4yza:A (1.25) BS08 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192094 4yza:A (1.25) BS09 GTR 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192095 4yza:A (1.25) BS10 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192096 4yza:B (1.25) BS01 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192097 4yza:B (1.25) BS02 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192098 4yza:B (1.25) BS03 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192099 4yza:B (1.25) BS04 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192100 4yza:B (1.25) BS05 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192101 4yza:B (1.25) BS06 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192102 4yza:B (1.25) BS07 GTR 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192103 4yza:B (1.25) BS08 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192104 4yzb:A (2.9) BS01 CA ? GO:0004672 ... Q3HNM4 N/A
    192105 4yzb:A (2.9) BS02 CA ? GO:0004672 ... Q3HNM4 N/A
    192106 4yzb:A (2.9) BS03 CA ? GO:0004672 ... Q3HNM4 N/A
    192107 4yzb:A (2.9) BS04 CA ? GO:0004672 ... Q3HNM4 N/A
    192108 4yzb:A (2.9) BS05 BK8 ? GO:0004672 ... Q3HNM4 N/A
    192109 4yzb:B (2.9) BS01 CA ? GO:0004672 ... Q3HNM4 N/A
    192110 4yzb:B (2.9) BS02 CA ? GO:0004672 ... Q3HNM4 N/A
    192111 4yzb:B (2.9) BS03 CA ? GO:0004672 ... Q3HNM4 N/A
    192112 4yzb:B (2.9) BS04 CA ? GO:0004672 ... Q3HNM4 N/A
    192113 4yzb:B (2.9) BS05 BK8 ? GO:0004672 ... Q3HNM4 N/A
    192114 4yzf:A (3.5) BS01 4KU ? GO:0005452 ... P02730 26542571
    192115 4yzf:B (3.5) BS01 4KU ? GO:0005452 ... P02730 26542571
    192116 4yzf:C (3.5) BS01 4KU ? GO:0005452 ... P02730 26542571
    192117 4yzf:D (3.5) BS01 4KU ? GO:0005452 ... P02730 26542571
    192118 4yzi:A (2.5) BS01 RET ? GO:0016020 ... Q8L435
    Q8RUT8    		 25975962
    192119 4yzi:A (2.5) BS02 ZN ? GO:0016020 ... Q8L435
    Q8RUT8    		 25975962
    192120 4yzq:A (1.48) BS01 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192121 4yzq:A (1.48) BS02 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192122 4yzq:A (1.48) BS03 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192123 4yzq:A (1.48) BS04 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192124 4yzq:A (1.48) BS05 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192125 4yzq:A (1.48) BS06 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192126 4yzq:A (1.48) BS07 GTR 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192127 4yzq:A (1.48) BS08 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192128 4yzq:B (1.48) BS01 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192129 4yzq:B (1.48) BS02 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192130 4yzq:B (1.48) BS03 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192131 4yzq:B (1.48) BS04 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192132 4yzq:B (1.48) BS05 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192133 4yzq:B (1.48) BS06 CA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192134 4yzq:B (1.48) BS07 GTR 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192135 4yzq:B (1.48) BS08 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192136 4yzq:B (1.48) BS09 ADA 4.2.2.2 GO:0005576 ... B9MKT4 26327384
    192137 4yzr:A (1.35) BS01 HIS 1.14.-.- GO:0004497 ... O31785 N/A
    192138 4yzr:A (1.35) BS02 HEM 1.14.-.- GO:0004497 ... O31785 N/A
    192139 4yzt:A (1.665) BS01 BGC 3.2.1.4 GO:0000272 ... Q65JI7 27032335
    192140 4yzt:A (1.665) BS02 BGC 3.2.1.4 GO:0000272 ... Q65JI7 27032335
    192141 4yzt:A (1.665) BS03 BGC 3.2.1.4 GO:0000272 ... Q65JI7 27032335
    192142 4yzv:QB (3.1) BS01 rna ? GO:0003735 ... P80371 26508639
    192143 4yzv:QC (3.1) BS01 rna ? GO:0003676 ... P80372 26508639
    192144 4yzv:QD (3.1) BS01 rna ? GO:0003723 ... P80373 26508639
    192145 4yzv:QD (3.1) BS02 MG ? GO:0003723 ... P80373 26508639
    192146 4yzv:QE (3.1) BS01 rna ? GO:0003723 ... Q5SHQ5 26508639
    192147 4yzv:QF (3.1) BS01 rna ? GO:0003735 ... Q5SLP8 26508639
    192148 4yzv:QG (3.1) BS01 rna ? GO:0000028 ... P17291 26508639
    192149 4yzv:QH (3.1) BS01 rna N/A GO:0003735 ... N/A 26508639
    192150 4yzv:QI (3.1) BS01 rna ? GO:0000049 ... P80374 26508639
    192151 4yzv:QI (3.1) BS02 rna ? GO:0000049 ... P80374 26508639
    192152 4yzv:QJ (3.1) BS01 rna ? GO:0000049 ... Q5SHN7 26508639
    192153 4yzv:QK (3.1) BS01 rna ? GO:0003735 ... P80376 26508639
    192154 4yzv:QK (3.1) BS02 rna ? GO:0003735 ... P80376 26508639
    192155 4yzv:QK (3.1) BS03 MG ? GO:0003735 ... P80376 26508639
    192156 4yzv:QL (3.1) BS01 rna ? GO:0000049 ... Q5SHN3 26508639
    192157 4yzv:QL (3.1) BS02 MG ? GO:0000049 ... Q5SHN3 26508639
    192158 4yzv:QM (3.1) BS01 rna ? GO:0000049 ... P80377 26508639
    192159 4yzv:QN (3.1) BS01 rna N/A GO:0003735 ... N/A 26508639
    192160 4yzv:QN (3.1) BS02 ZN N/A GO:0003735 ... N/A 26508639
    192161 4yzv:QN (3.1) BS03 MG N/A GO:0003735 ... N/A 26508639
    192162 4yzv:QO (3.1) BS01 rna ? GO:0003735 ... Q5SJ76 26508639
    192163 4yzv:QO (3.1) BS02 rna ? GO:0003735 ... Q5SJ76 26508639
    192164 4yzv:QP (3.1) BS01 rna ? GO:0003735 ... Q5SJH3 26508639
    192165 4yzv:QQ (3.1) BS01 rna N/A GO:0003735 ... N/A 26508639
    192166 4yzv:QR (3.1) BS01 rna ? GO:0003735 ... Q5SLQ0 26508639
    192167 4yzv:QS (3.1) BS01 rna ? GO:0000028 ... Q5SHP2 26508639
    192168 4yzv:QT (3.1) BS01 rna ? GO:0003723 ... P80380 26508639
    192169 4yzv:R0 (3.1) BS01 rna ? GO:0003735 ... P60493 26508639
    192170 4yzv:R0 (3.1) BS02 rna ? GO:0003735 ... P60493 26508639
    192171 4yzv:R0 (3.1) BS03 rna ? GO:0003735 ... P60493 26508639
    192172 4yzv:R1 (3.1) BS01 rna ? GO:0003735 ... P60494 26508639
    192173 4yzv:R2 (3.1) BS01 rna ? GO:0003735 ... Q5SHP6 26508639
    192174 4yzv:R3 (3.1) BS01 rna ? GO:0003735 ... Q5SHQ6 26508639
    192175 4yzv:R3 (3.1) BS02 rna ? GO:0003735 ... Q5SHQ6 26508639
    192176 4yzv:R4 (3.1) BS01 rna ? GO:0003735 ... Q5SJE1 26508639
    192177 4yzv:R4 (3.1) BS02 rna ? GO:0003735 ... Q5SJE1 26508639
    192178 4yzv:R5 (3.1) BS01 rna ? GO:0003735 ... P80339 26508639
    192179 4yzv:R5 (3.1) BS02 MG ? GO:0003735 ... P80339 26508639
    192180 4yzv:R6 (3.1) BS01 rna ? GO:0000049 ... P35871 26508639
    192181 4yzv:R7 (3.1) BS01 rna ? GO:0003735 ... P80340 26508639
    192182 4yzv:R8 (3.1) BS01 rna ? GO:0003735 ... Q5SKU1 26508639
    192183 4yzv:R9 (3.1) BS01 rna ? GO:0003735 ... Q5SHR2 26508639
    192184 4yzv:RD (3.1) BS01 rna ? GO:0002181 ... P60405 26508639
    192185 4yzv:RD (3.1) BS02 rna ? GO:0002181 ... P60405 26508639
    192186 4yzv:RD (3.1) BS03 MG ? GO:0002181 ... P60405 26508639
    192187 4yzv:RE (3.1) BS01 rna ? GO:0003735 ... Q5SHN8 26508639
    192188 4yzv:RF (3.1) BS01 rna ? GO:0003735 ... Q5SHN9 26508639
    192189 4yzv:RF (3.1) BS02 MG ? GO:0003735 ... Q5SHN9 26508639
    192190 4yzv:RF (3.1) BS03 MG ? GO:0003735 ... Q5SHN9 26508639
    192191 4yzv:RG (3.1) BS01 rna ? GO:0000049 ... Q5SHQ0 26508639
    192192 4yzv:RG (3.1) BS02 rna ? GO:0000049 ... Q5SHQ0 26508639
    192193 4yzv:RG (3.1) BS03 rna ? GO:0000049 ... Q5SHQ0 26508639
    192194 4yzv:RH (3.1) BS01 rna N/A GO:0003735 ... N/A 26508639
    192195 4yzv:RI (3.1) BS01 rna ? GO:0003735 ... Q5SLQ1 26508639
    192196 4yzv:RN (3.1) BS01 rna ? GO:0003729 ... P60488 26508639
    192197 4yzv:RO (3.1) BS01 rna ? GO:0003735 ... Q5SHP8 26508639
    192198 4yzv:RO (3.1) BS02 rna ? GO:0003735 ... Q5SHP8 26508639
    192199 4yzv:RP (3.1) BS01 rna ? GO:0003735 ... Q5SHQ7 26508639
    192200 4yzv:RP (3.1) BS02 MG ? GO:0003735 ... Q5SHQ7 26508639
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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