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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	leukotriene E4
Molecular formula	C23H37NO5S
IUPAC name	(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Molecular weight	439.611
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	2.1
Synonyms	[5S-[5R,6S(S),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoate 1826AH BSPBio_001370 GTPL3352 NCGC00163400-01 (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid 29819-EP2305640A2 7,9,11,14-Eicosatetraenoic acid, 6-((2-amino-2-carboxyethyl)thio)-5-hydroxy-, (5S-(5R,6S(S),7E,9E,11Z,14Z))- CHEBI:15650 LEUKOTRIEN E4 S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine ZINC4629873 (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate AC1NQXPM D0C0KJ LMFA03020002 [5S-[5R,6S(S),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoic acid (5S,6R,7E,9E,11Z,14Z)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoic acidS-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine 29819-EP2272832A1 5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid C05952 GTPL5863 NCGC00163400-02 (5S,6R,7E,9E,11Z,14Z)-6-[[(2R)-2-Amino-2-carboxyethyl]thio]-5-hydroxy-7,9,11,14-eicosatetraenoic Acid 29819-EP2311832A1 75715-89-8 Leukotriene E SCHEMBL11263165 [3H]LTE4 (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate BDBM50297387 D0Z3BL LTE4 (5S,6R,7E,9E,11Z,14Z)-6-(L-cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid 29819-EP2281815A1 5S-Hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid C23H37NO5S HMS3402E12 OTZRAYGBFWZKMX-FRFVZSDQSA-N UNII-8EYT8ATL7G (5S-(5R,6S(S),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid 29819-EP2311833A1 8EYT8ATL7G CHEMBL509456 [ Show all ]
Inchi Key	OTZRAYGBFWZKMX-FRFVZSDQSA-N
Inchi ID	InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
PubChem CID	5280879
ChEMBL	CHEMBL509456
IUPHAR	5863, 3352
BindingDB	50297387
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
554514	2-oxoglutarate receptor 1	Q6IYF8	Oxgr1	Mus musculus (Mouse)	337
554511	Cysteinyl leukotriene receptor 1	Q9Y271	CYSLTR1	Homo sapiens (Human)	337
554512	Cysteinyl leukotriene receptor 2	Q9NS75	CYSLTR2	Homo sapiens (Human)	346
556437	Leukotriene B4 receptor 1	Q15722	LTB4R	Homo sapiens (Human)	352
461378	Leukotriene B4 receptor 2	Q9NPC1	LTB4R2	Homo sapiens (Human)	358
250374	P2Y purinoceptor 12	Q9H244	P2RY12	Homo sapiens (Human)	342
554513	Uracil nucleotide/cysteinyl leukotriene receptor	Q6NS65	Gpr17	Mus musculus (Mouse)	339

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