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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	AST 487
Molecular formula	C26H30F3N7O2
IUPAC name	1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea
Molecular weight	529.568
Hydrogen bond acceptor	10
Hydrogen bond donor	3
XlogP	3.8
Synonyms	KB-74747 SCHEMBL1684259 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea cid_11409972 DTXSID70212239 NCGC00354729-03 Urea, N-(4-((4-ethyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-N'-(4-((6-(methylamino)-4-pyrimidinyl)oxy)phenyl)- 3-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-1-(4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)urea AST-487/AST487 HY-15002 NVP-AST487 ZINC23247639 630124-46-8 C26H30F3N7O2 Kinome_3855 SYN1210 1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea AST-48 CS-0779 EX-A1374 NVP-AST 487 W-5519 BCP21589 J-519601 RL04396 1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea AKOS030526863 CHEMBL574738 MolPort-028-617-380 UNII-W34UO2M4T6 1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea AST-487 D0N7AJ GTPL5661 NVP-AST-487 W34UO2M4T6 3455AH BDBM31085 [ Show all ]
Inchi Key	ODPGGGTTYSGTGO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
PubChem CID	11409972
ChEMBL	N/A
IUPHAR	N/A
BindingDB	31085
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
461270	P2Y purinoceptor 14	Q15391	P2RY14	Homo sapiens (Human)	338

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