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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL2381089
Molecular formula	C25H25F3N4OS
IUPAC name	(2-methyl-5-phenyl-1,3-thiazol-4-yl)-[(6S)-6-[[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]amino]methyl]-5-azaspiro[2.4]heptan-5-yl]methanone
Molecular weight	486.557
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	5.8
Synonyms	SCHEMBL16267433
Inchi Key	AJNCVXFJWXFNFR-IBGZPJMESA-N
Inchi ID	InChI=1S/C25H25F3N4OS/c1-15-10-18(25(26,27)28)11-20(30-15)29-13-19-12-24(8-9-24)14-32(19)23(33)21-22(34-16(2)31-21)17-6-4-3-5-7-17/h3-7,10-11,19H,8-9,12-14H2,1-2H3,(H,29,30)/t19-/m0/s1
PubChem CID	71602482
ChEMBL	CHEMBL2381089
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
7061	Orexin receptor type 1	O43613	HCRTR1	Homo sapiens (Human)	425
7060	Orexin receptor type 2	O43614	HCRTR2	Homo sapiens (Human)	444

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