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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL3965933
Molecular formula	C19H20F3N5O
IUPAC name	3-cyclopropyl-N-[(1S,2S)-2-[[5-(trifluoromethyl)pyrazin-2-yl]amino]cyclopentyl]pyridine-2-carboxamide
Molecular weight	391.398
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	3.1
Synonyms	US9156829, 63 AFBKMNNXFDRXES-KBPBESRZSA-N BDBM185247 SCHEMBL17007240 3-Cyclopropyl-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]pyridine-2-carboxamide
Inchi Key	AFBKMNNXFDRXES-KBPBESRZSA-N
Inchi ID	InChI=1S/C19H20F3N5O/c20-19(21,22)15-9-25-16(10-24-15)26-13-4-1-5-14(13)27-18(28)17-12(11-6-7-11)3-2-8-23-17/h2-3,8-11,13-14H,1,4-7H2,(H,25,26)(H,27,28)/t13-,14-/m0/s1
PubChem CID	118308193
ChEMBL	CHEMBL3965933
IUPHAR	N/A
BindingDB	185247
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
536024	Orexin receptor type 1	O43613	HCRTR1	Homo sapiens (Human)	425
536025	Orexin receptor type 2	O43614	HCRTR2	Homo sapiens (Human)	444

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