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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL134877
Molecular formulaC26H28N4O
IUPAC name2-[4-(3,3-diphenylpropanoyl)piperazin-1-yl]-2-(1-methylpyrrol-3-yl)acetonitrile
Molecular weight412.537
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.1
SynonymsBDBM50003535
[4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(1-methyl-1H-pyrrol-3-yl)-acetonitrile
2-[4-(3,3-Diphenylpropionyl)-1-piperazinyl]-2-(1-methyl-1H-pyrrol-3-yl)acetonitrile
Inchi KeyGLGGFRRLQSUHIT-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H28N4O/c1-28-13-12-23(20-28)25(19-27)29-14-16-30(17-15-29)26(31)18-24(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-13,20,24-25H,14-18H2,1H3
PubChem CID10364365
ChEMBLCHEMBL134877
IUPHARN/A
BindingDB50003535
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID504.2 mg.kg-1PMID1433215ChEMBL

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