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Name | Free fatty acid receptor 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR2 |
Synonym | FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 [ Show all ] |
Disease | Abortion Diabetes |
Length | 330 |
Amino acid sequence | MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE |
UniProt | O15552 |
Protein Data Bank | N/A |
GPCR-HGmod model | O15552 |
3D structure model | This predicted structure model is from GPCR-EXP O15552. |
BioLiP | N/A |
Therapeutic Target Database | T28213 |
ChEMBL | CHEMBL5493 |
IUPHAR | 226 |
DrugBank | N/A |
Name | CHEMBL608129 |
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Molecular formula | C13H15ClN2O2S2 |
IUPAC name | N-[(1S)-1-(4-chlorophenyl)-2-methylpropyl]-1,3-thiazole-2-sulfonamide |
Molecular weight | 330.845 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 3.7 |
Synonyms | BDBM50305941 (S)-N-(1-(4-chlorophenyl)-2-methylpropyl)thiazole-2-sulfonamide |
Inchi Key | ANVFXULCLQTBRH-LBPRGKRZSA-N |
Inchi ID | InChI=1S/C13H15ClN2O2S2/c1-9(2)12(10-3-5-11(14)6-4-10)16-20(17,18)13-15-7-8-19-13/h3-9,12,16H,1-2H3/t12-/m0/s1 |
PubChem CID | 46226105 |
ChEMBL | CHEMBL608129 |
IUPHAR | N/A |
BindingDB | 50305941 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Efficacy | >30.0 % | PMID20005104 | ChEMBL |
IC50 | <100000.0 nM | PMID20005104 | BindingDB,ChEMBL |
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