You can:
Name | B2 bradykinin receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | BDKRB2 |
Synonym | B2R BK-2 receptor |
Disease | N/A for non-human GPCRs |
Length | 372 |
Amino acid sequence | MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL |
UniProt | O70526 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4111 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL538784 |
---|---|
Molecular formula | C34H35N7O6 |
IUPAC name | 1-N,3-N-dimethyl-4-[methyl-[2-[[(E)-3-[6-(methylcarbamoyl)pyridin-3-yl]prop-2-enoyl]amino]acetyl]amino]-2-[(2-methylquinolin-8-yl)oxymethyl]benzene-1,3-dicarboxamide |
Molecular weight | 637.697 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 4 |
XlogP | 1.9 |
Synonyms | BDBM50067922 N*1*,N*3*-Dimethyl-4-(methyl-{2-[3-(6-methylcarbamoyl-pyridin-3-yl)-acryloylamino]-acetyl}-amino)-2-(2-methyl-quinolin-8-yloxymethyl)-isophthalamide CHEMBL1189464 |
Inchi Key | GKUUBNIYKXZAGT-LFIBNONCSA-N |
Inchi ID | InChI=1S/C34H35N7O6/c1-20-9-12-22-7-6-8-27(31(22)40-20)47-19-24-23(32(44)35-2)13-15-26(30(24)34(46)37-4)41(5)29(43)18-39-28(42)16-11-21-10-14-25(38-17-21)33(45)36-3/h6-17H,18-19H2,1-5H3,(H,35,44)(H,36,45)(H,37,46)(H,39,42)/b16-11+ |
PubChem CID | 44360879 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50067922 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.68 nM | PMID9804698 | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417