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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Mu-type opioid receptor
Species	Bos taurus (Bovine)
Gene	OPRM1
Synonym	M-OR-1 MOR-1
Disease	N/A for non-human GPCRs
Length	401
Amino acid sequence	MDSGAVPTNASNCTDPFTHPSSCSPAPSPSSWVNFSHLEGNLSDPCGPNRTELGGSDRLCPSAGSPSMITAIIIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDLRTPRNAKIINICNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPILIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETTPLP
UniProt	P79350
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3041
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3038193
Molecular formula	C31H41NO5Si
IUPAC name	(5R)-5-[(1R,2S,6R,14R,15R,16R)-11-[tert-butyl(dimethyl)silyl]oxy-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,18-tetraen-16-yl]-3-methylideneoxolan-2-one
Molecular weight	535.756
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	None
Synonyms	BDBM50013768 3-O-(tert-Butyldimethylsilyl)-6,14-endo-etheno-7alpha-(3-carboxy-3-n-butenyl) tetrahydrooripavine gama-Lactone
Inchi Key	GKSKATUWAYLQMB-PNNRCKMPSA-N
Inchi ID	InChI=1S/C31H41NO5Si/c1-18-15-22(35-26(18)33)20-17-29-11-12-31(20,34-6)27-30(29)13-14-32(5)23(29)16-19-9-10-21(25(36-27)24(19)30)37-38(7,8)28(2,3)4/h9-12,20,22-23,27H,1,13-17H2,2-8H3/t20-,22-,23-,27-,29-,30+,31-/m1/s1
PubChem CID	73352755
ChEMBL	CHEMBL3038193
IUPHAR	N/A
BindingDB	50013768
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
IC50	34.0 nM	PMID2165166	BindingDB,ChEMBL

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