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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL13930
Molecular formulaC28H34N4O3
IUPAC name2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-ylpropan-2-yl]-2-methylpropanamide
Molecular weight474.605
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP3.3
Synonyms1N-[2-(1,3,4,4a,5,10a-hexahydro-2H-chromeno[2,3-c]pyridin-2-yl)-1-(1H-3-indolylmethyl)-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide
BDBM50073041
SCHEMBL5015233
Inchi KeyGKDDEWIPWZXMHC-HSZRJFAPSA-N
Inchi IDInChI=1S/C28H34N4O3/c1-27(2,29)26(34)31-23(17-20-18-30-22-9-5-4-8-21(20)22)25(33)32-15-13-28(14-16-32)12-11-19-7-3-6-10-24(19)35-28/h3-10,18,23,30H,11-17,29H2,1-2H3,(H,31,34)/t23-/m1/s1
PubChem CID22862431
ChEMBLCHEMBL13930
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5025.0 nMPMID9925440ChEMBL

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