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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Rattus norvegicus (Rat)
Gene	Htr1b
Synonym	HTR1D2 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 5-HT1Dbeta 5-HT1DB 5-HT1B serotonin receptor 5-HT1B receptor 5-HT1B 5-HT-1B Serotonin receptor 1B [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
UniProt	P28564
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3459
IUPHAR	2
DrugBank	N/A

Ligand

Name	clonidine
Molecular formula	C9H9Cl2N3
IUPAC name	N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Molecular weight	230.092
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.6
Synonyms	Bio1_001448 LS-79606 BSPBio_001588 1416-EP2272841A1 MRF-0000018 CATAPRES-TTS-1 1416-EP2308839A1 NCGC00015268-05 Catarpresan 2,6-dichloro-N-(2-imidazolidinylidene)aniline NCGC00024734-05 Chlornidinum 2-(2,6-dichlorophenyl-imino)-imidazolidine Prestwick1_000248 Clonidine (JAN/USAN/INN) 2-[(2,6-dichlorophenyl)amino]-2-imidazoline SPBio_001233 Clonidinum [INN-Latin] SR-01000759380-4 DB00575 AB00514634_09 Tox21_110118_1 Duraclont KBio2_002876 BCP07223 HMS1791P10 KBioGR_001572 Klofelin BPBio1_000040 M199 CAS-4205-91-8 1416-EP2295406A1 N-(2,6-dichlorophenyl)imidazolidin-2-imine Catapresan 1416-EP2314571A2 NCGC00015268-08 CHEBI:3757 2,6-dichloro-N-imidazolidin-2-ylideneaniline NCGC00179680-03 Clonidina 2-(2,6-Dichlorophenylimino)imidazolidine SBI-0050256.P004 Clonidine [USAN:BAN:INN] 2-[(2,6-Dichlorophenyl)imino]imidazolidine Spectrum3_000358 Combipres 734571A ST-155BS DSSTox_CID_2846 Isoglaucon Adesipress ZINC896484 Gemiton KBio2_006957 BDBM50225285 HMS3402P10 IDI1_034058 Lopac-C-7897 BRD-K98530306-003-07-6 MN3L5RMN02 Catapres- TTS 1416-EP2298772A1 NCGC00015268-03 Catarpres-TTS 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (9CI) NCGC00024734-03 CHEMBL134 2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2) NINDS_000774 clonidine (amino form) 2-Imidazoline, 2-(2,6-dichloroanilino)-(7CI,8CI) SKF 34427 Clonidinhydrochlorid 4205-90-7 Spectrum_001341 D03SKR AB00514634-07 Tocris-0690 DTXSID6022846 KBio2_000308 API0002069 Hemiton KBio3_001275 Bio1_000470 Bio2_000308 M 5041T BSPBio_002055 1416-EP2280010A2 N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine CATAPRES-TTS-2 1416-EP2308867A2 NCGC00015268-06 CCG-204363 2,6-dichloro-N-2-imidazolidinylidenebenzenamide NCGC00179680-01 Clofenil 2-(2,6-Dichlorophenylamino)-2-imidazoline Prestwick2_000248 Clonidine (JAN/USP/INN) 2-[(2,6-dichlorophenyl)imino]-2-imidazoline SPBio_002255 Clopheline ST 155BS DivK1c_000774 AC1L1EI5 UNII-MN3L5RMN02 EINECS 224-119-4 KBio2_004389 BDBM14062 HMS1989P10 KBioSS_000308 HSDB 3040 Klofenil BRD-K98530306-001-02-1 (2,6-dichloro-phenyl)-imidazolidin-2-ylidene-amine MCULE-5017779690 Catapres 1416-EP2298764A1 NCGC00015268-01 Catapressan 1416-EP2314585A1 NCGC00024734-01 CHEBI:46632 2-((2,6-Dichlorophenyl)imino)imidazolidine NCGC00179680-05 Clonidina [INN-Spanish] 2-Imidazoline, 2-(2,6-dichloroanilino)- SC-47255 Clonidine [USAN:USP:INN:BAN] 2-[(2,6-Dichlorophenyl)imino]imidazoline Spectrum4_000956 D00281 AB00053441_03 STL355995 DSSTox_GSID_22846 Kapvay® AKOS001595470 [3H]clonidine GJSURZIOUXUGAL-UHFFFAOYSA-N KBio3_000615 Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene- Lopac0_000268 BSPBio_000036 1416-EP2269989A1 MolPort-001-779-668 Catapres-TTS 1416-EP2301936A1 NCGC00015268-04 Catarpres-TTS (TN) 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-(9CI) NCGC00024734-04 Chlofazoline 2-(2,6-Dichloroanilino)-2-imidazoline Prestwick0_000248 clonidine (imino form) 2-IMIDAZOLINE, 2-(2,6-DICHLOROPHENYLAMINO)- SMR001550184 Clonidinum 4205-91-8 (mono-hydrochloride) SR-01000759380 AB00514634-08 Tox21_110118 Duraclon KBio2_001821 BBL025137 HMS1361P10 KBioGR_000308 Bio1_000959 Bio2_000788 M-5041T CAS-4205-90-7 1416-EP2281559A1 N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine # CATAPRES-TTS-3 1416-EP2308870A2 NCGC00015268-07 CCRIS 7787 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine NCGC00179680-02 Clonidin 2-(2,6-dichlorophenylimino)-imidazolidine Prestwick3_000248 Clonidine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 2-[(2,6-dichlorophenyl)imino]-imidazolidine Spectrum2_001187 CLORPRES 57066-25-8 ST-155-BS Dixarit AC1Q3K6V ZB015091 FT-0741246 KBio2_005444 BDBM50016897 HMS2089G11 KBioSS_001821 IDI1_000774 L000193 BRD-K98530306-003-05-0 (2,6-Dichlorophenyl)imidazolidin-2-ylidene amine MLS006011925 Catapres (TN) 1416-EP2298765A1 NCGC00015268-02 Catarpres 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- NCGC00024734-02 2-(2',6'-dichlorophenylamino)-2-imidazoline Nexiclon XR 2-Imidazoline, 2-(2,6-dichloroanilino)- (7CI,8CI) SCHEMBL5982 CLONIDINE, Clonidine hydrochloride 3h-clonidine Spectrum5_000759 D02AZT AB00514634 Tenso-Timelets DSSTox_RID_76756 KBio1_000774 AKOS015960367 GTPL516 KBio3_000616 BIDD:GT0547 [ Show all ]
Inchi Key	GJSURZIOUXUGAL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
PubChem CID	2803
ChEMBL	CHEMBL134
IUPHAR	516
BindingDB	50016897
DrugBank	DB00575
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID1738111	BindingDB

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