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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	Chloromethyl Thienyl Ketone deriv. 9
Molecular formula	C9H8Cl2O2S
IUPAC name	2-chloro-1-[4-(2-chloroacetyl)-5-methylthiophen-2-yl]ethanone
Molecular weight	251.121
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.9
Synonyms	AC1O6Z8G CHEMBL143743 2-chloro-1-[4-(2-chloroacetyl)-5-methylthiophen-2-yl]ethan-1-one BDBM7861 2-chloro-1-[4-(2-chloroacetyl)-5-methylthiophen-2-yl]ethanone SCHEMBL6795205 [ Show all ]
Inchi Key	GJRQVIGIYKVADY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H8Cl2O2S/c1-5-6(7(12)3-10)2-9(14-5)8(13)4-11/h2H,3-4H2,1H3
PubChem CID	6539176
ChEMBL	CHEMBL143743
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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