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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Sus scrofa (Pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	137
Amino acid sequence	CCQPLVYRNKMTPLRVAVLLAGCWAIPVLISFLPIMQGWNNIGITDLIEKRKFHQNSNSTYCIFMVNKPYAITCSVVAFYIPFLLMVLAYWRIYVTAKEHAHQIQMLQRAGAPAEGRPPSADQHSTHRMRTETKAAK
UniProt	Q29006
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SB 242084
Molecular formula	C21H19ClN4O2
IUPAC name	6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide
Molecular weight	394.859
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide BDBM85097 GTPL193 AC1MUPO0 CHEMBL14563 NCGC00186029-01 SB-242084 1215566-78-1 API0006977 DTXSID70394600 PDSP2_001553 ZINC602170 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide Dihydrochloride Hydrate CAS_181632-25-7 HY-13409 SB 242084 hydrochloride AJ-23679 CS-4329 NCGC00186029-02 SB242084 BCP07316 EX-A2270 S-7715 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline AB0089377 L000542 SB-242,084 AKOS032945733 D00EMF PDSP1_001569 SCHEMBL507945 1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-(6-((2-methyl-3-pyridinyl)oxy)-3-pyridinyl)- [ Show all ]
Inchi Key	GIUZEIJUFOPTMR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H19ClN4O2/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27)
PubChem CID	3644637
ChEMBL	CHEMBL14563
IUPHAR	193
BindingDB	85097
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3162.27 nM	PMID9225286	BindingDB

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