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GPCR

NameType-1 angiotensin II receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
UniProtP34976
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3948
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2237609
Molecular formulaC29H30N8O2
IUPAC nameN-[4-[[3-butyl-5-(2-phenylethoxy)-1,2,4-triazol-4-yl]methyl]phenyl]-2-(2H-tetrazol-5-yl)benzamide
Molecular weight522.613
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP5.1
SynonymsN/A
Inchi KeyANMOOVWZHUIRCD-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H30N8O2/c1-2-3-13-26-31-34-29(39-19-18-21-9-5-4-6-10-21)37(26)20-22-14-16-23(17-15-22)30-28(38)25-12-8-7-11-24(25)27-32-35-36-33-27/h4-12,14-17H,2-3,13,18-20H2,1H3,(H,30,38)(H,32,33,35,36)
PubChem CID76315369
ChEMBLCHEMBL2237609
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5063.0 nMMed Chem Res, (2012) 21:9:2307ChEMBL

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