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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL593517
Molecular formulaC14H15ClN2OS
IUPAC nameN-[(1S)-1-(4-chlorophenyl)-2-methylpropyl]-1,3-thiazole-2-carboxamide
Molecular weight294.797
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.1
Synonyms(S)-N-(1-(4-chlorophenyl)-2-methylpropyl)thiazole-2-carboxamide
BDBM50305977
Inchi KeyANKYYXZDVDOIMS-LBPRGKRZSA-N
Inchi IDInChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)17-13(18)14-16-7-8-19-14/h3-9,12H,1-2H3,(H,17,18)/t12-/m0/s1
PubChem CID46225341
ChEMBLCHEMBL593517
IUPHARN/A
BindingDB50305977
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy>30.0 %PMID20005104ChEMBL
IC50<100000.0 nMPMID20005104BindingDB,ChEMBL

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