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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL240287
Molecular formula	C34H45N3O3
IUPAC name	3-[1-hydroxy-2-(hydroxymethyl)butan-2-yl]-1-[2-[1-[(4-methylphenyl)methyl]piperidin-4-yl]ethyl]-1-[(4-phenylphenyl)methyl]urea
Molecular weight	543.752
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	5.1
Synonyms	BDBM50209690 1-(4-biphenylmethyl)-3-[1,1-di(hydroxymethyl)propyl]-1-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}urea
Inchi Key	ANKIQEZFSWFNLV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H45N3O3/c1-3-34(25-38,26-39)35-33(40)37(24-30-13-15-32(16-14-30)31-7-5-4-6-8-31)22-19-28-17-20-36(21-18-28)23-29-11-9-27(2)10-12-29/h4-16,28,38-39H,3,17-26H2,1-2H3,(H,35,40)
PubChem CID	44437622
ChEMBL	CHEMBL240287
IUPHAR	N/A
BindingDB	50209690
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Imax	93.5 %	PMID17407817	ChEMBL
Kb	147.0 nM	PMID17407817	ChEMBL
Ki	173.0 nM	PMID20932767, PMID17407817	BindingDB,ChEMBL
Ki	173.78 nM	PMID20932767, PMID17407817	ChEMBL
pKb	6.835 -	PMID17407817	ChEMBL

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