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GPCR

NameAlpha-2A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA2A
SynonymAlpha-2A adrenoceptor
Alpha-2A adrenoreceptor
Alpha-2AAR
Alpha-2D adrenergic receptor
DiseaseN/A for non-human GPCRs
Length452
Amino acid sequenceMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtQ28838
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4744
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL349776
Molecular formulaC14H19NO2
IUPAC name(4aS,10bR)-7-methoxy-4-methyl-1,2,3,4a,5,10b-hexahydrochromeno[3,4-b]pyridine
Molecular weight233.311
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP2.3
SynonymsBDBM50016887
GFCDMVGEDLAHIF-ZYHUDNBSSA-N
trans-7-methoxy-4-methyl-1,2,3,4a,5,10b-hexahydro-4H-[1]-benzopyrano[3,4-b]pyridine
8-Methoxy-1-methyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene
Inchi KeyGFCDMVGEDLAHIF-ZYHUDNBSSA-N
Inchi IDInChI=1S/C14H19NO2/c1-15-8-4-6-10-11-5-3-7-13(16-2)14(11)17-9-12(10)15/h3,5,7,10,12H,4,6,8-9H2,1-2H3/t10-,12-/m1/s1
PubChem CID14151633
ChEMBLCHEMBL349776
IUPHARN/A
BindingDB50016887
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Change-24.0 %PMID2537429ChEMBL

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