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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000046638
Molecular formula	C21H32N2O3S
IUPAC name	(4-benzylpiperidin-1-yl)-(1-propylsulfonylpiperidin-3-yl)methanone
Molecular weight	392.558
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.1
Synonyms	NCGC00050246-02 BDBM37695 cid_3237289 [4-(phenylmethyl)-1-piperidinyl]-(1-propylsulfonyl-3-piperidinyl)methanone (4-benzylpiperidin-1-yl)-(1-propylsulfonylpiperidin-3-yl)methanone HMS3308J21 REGID_for_CID_3237289 EU-0098038 [4-(phenylmethyl)piperidin-1-yl]-(1-propylsulfonylpiperidin-3-yl)methanone (4-benzylpiperidino)-(1-propylsulfonyl-3-piperidyl)methanone AC1MME1E CHEMBL1430943 SMR000032649 HMS2157J07 3-[(4-benzylpiperidin-1-yl)carbonyl]-1-(propylsulfonyl)piperidine [ Show all ]
Inchi Key	ANDSXDKABIYGPB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H32N2O3S/c1-2-15-27(25,26)23-12-6-9-20(17-23)21(24)22-13-10-19(11-14-22)16-18-7-4-3-5-8-18/h3-5,7-8,19-20H,2,6,9-17H2,1H3
PubChem CID	3237289
ChEMBL	CHEMBL1430943
IUPHAR	N/A
BindingDB	37695
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	7943.3 nM	PubChem BioAssay data set	ChEMBL

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