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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
TaR-7b
Trace amine receptor 12
Trace amine receptor 7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3702011
Molecular formulaC19H20N4O
IUPAC nameN-[4-[(2S)-morpholin-2-yl]phenyl]-5-phenyl-1H-pyrazol-3-amine
Molecular weight320.396
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP2.8
SynonymsSCHEMBL12609901
Inchi KeyGDVHMMRWGWZVGE-GOSISDBHSA-N
Inchi IDInChI=1S/C19H20N4O/c1-2-4-14(5-3-1)17-12-19(23-22-17)21-16-8-6-15(7-9-16)18-13-20-10-11-24-18/h1-9,12,18,20H,10-11,13H2,(H2,21,22,23)/t18-/m1/s1
PubChem CID68325640
ChEMBLCHEMBL3702011
IUPHARN/A
BindingDB129471
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki87.7 nM, NoneBindingDB,ChEMBL

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