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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	CHEMBL65779
Molecular formula	C24H23ClFNO5S
IUPAC name	3-[3-[2-[(4-chlorophenyl)sulfonylamino]ethyl]-5-[(4-fluorophenyl)-hydroxymethyl]phenyl]propanoic acid
Molecular weight	491.958
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	4.1
Synonyms	BDBM50403666 GDUHKNXVKCKPIA-UHFFFAOYSA-N SCHEMBL8594726 3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)hydroxymethyl]benzenepropanoic acid
Inchi Key	GDUHKNXVKCKPIA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H23ClFNO5S/c25-20-4-8-22(9-5-20)33(31,32)27-12-11-17-13-16(1-10-23(28)29)14-19(15-17)24(30)18-2-6-21(26)7-3-18/h2-9,13-15,24,27,30H,1,10-12H2,(H,28,29)
PubChem CID	19962351
ChEMBL	CHEMBL65779
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	0.1995 nM	PMID9873486	ChEMBL

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