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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	2-methoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Molecular formula	C20H25N3O2
IUPAC name	2-methoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Molecular weight	339.439
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	2-methoxy-N-(2-(4-phenylpiperazin-1-yl)ethyl)benzamide cid_747202 2-methoxy-N-[2-(4-phenylpiperazino)ethyl]benzamide Oprea1_339845 BDBM114629 SR-01000216910-3 2-methoxy-N-[2-(4-phenyl-1-piperazinyl)ethyl]benzamide F5264-0059 AC1LF5IA Oprea1_699641 CHEMBL1622074 ZINC55111898 MCULE-7250395909 AKOS024728174 SR-01000216910 [ Show all ]
Inchi Key	GCTHHCZLCQZWOP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25N3O2/c1-25-19-10-6-5-9-18(19)20(24)21-11-12-22-13-15-23(16-14-22)17-7-3-2-4-8-17/h2-10H,11-16H2,1H3,(H,21,24)
PubChem CID	747202
ChEMBL	N/A
IUPHAR	N/A
BindingDB	114629
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92470.0 nM	N/A	BindingDB

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