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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Homo sapiens (Human)
Gene	LHCGR
Synonym	lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor [ Show all ]
Disease	Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility Fertility Leukemia Infertility [ Show all ]
Length	699
Amino acid sequence	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProt	P22888
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79473
ChEMBL	CHEMBL1854
IUPHAR	N/A
DrugBank	BE0000134

Ligand

Name	1-[2-(4-fluorophenyl)ethyl]-3-(4-nitrophenyl)thiourea
Molecular formula	C15H14FN3O2S
IUPAC name	1-[2-(4-fluorophenyl)ethyl]-3-(4-nitrophenyl)thiourea
Molecular weight	319.354
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.4
Synonyms	ZINC8682754 HMS2572A09 MolPort-001-594-850 ST50841066 {[2-(4-fluorophenyl)ethyl]amino}[(4-nitrophenyl)amino]methane-1-thione MCULE-2482042444 N-[2-(4-fluorophenyl)ethyl]-N'-(4-nitrophenyl)thiourea AC1MG9NK STK455765 CHEMBL1311052 MLS000581445 SMR000200070 AKOS003325081 [ Show all ]
Inchi Key	GBFSFYSCDBSPJY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H14FN3O2S/c16-12-3-1-11(2-4-12)9-10-17-15(22)18-13-5-7-14(8-6-13)19(20)21/h1-8H,9-10H2,(H2,17,18,22)
PubChem CID	2957683
ChEMBL	CHEMBL1311052
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	268545.0 nM	PubChem BioAssay data set	ChEMBL

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