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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL213873
Molecular formulaC27H28F3N3O
IUPAC name(E)-N-(4-piperidin-1-yl-2-propylquinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
Molecular weight467.536
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP6.5
SynonymsBDBM50193607
(E)-N-(4-(piperidin-1-yl)-2-propylquinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide
Inchi KeyAMQCCJITDXPYII-NTEUORMPSA-N
Inchi IDInChI=1S/C27H28F3N3O/c1-2-6-21-18-25(33-15-4-3-5-16-33)23-17-22(12-13-24(23)31-21)32-26(34)14-9-19-7-10-20(11-8-19)27(28,29)30/h7-14,17-18H,2-6,15-16H2,1H3,(H,32,34)/b14-9+
PubChem CID10310778
ChEMBLCHEMBL213873
IUPHARN/A
BindingDB50193607
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition>50.0 %PMID16919453ChEMBL

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