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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Homo sapiens (Human)
Gene	CHRM3
Synonym	cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 M3 receptor M3R [ Show all ]
Disease	Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease Glaucoma Diagnosing bronchial hyperreactivity Chronic obstructive pulmonary disease Seborrhea Sjogren's syndrome Spasms; Pain Unspecified Alzheimer disease Obstructive lung diseases [ Show all ]
Length	590
Amino acid sequence	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
UniProt	P20309
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T67684
ChEMBL	CHEMBL245
IUPHAR	15
DrugBank	BE0000045

Ligand

Name	CHEMBL1084941
Molecular formula	C19H15N3O2
IUPAC name	1-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]indole-2,3-dione
Molecular weight	317.348
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.3
Synonyms	VU0365137 BDBM50313639 cid_44251554 1-(4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione VU0365137-1 SCHEMBL17207999 [ Show all ]
Inchi Key	FZOKIVAOPLLMAV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15N3O2/c1-21-12-15(10-20-21)14-8-6-13(7-9-14)11-22-17-5-3-2-4-16(17)18(23)19(22)24/h2-10,12H,11H2,1H3
PubChem CID	44251554
ChEMBL	CHEMBL1084941
IUPHAR	N/A
BindingDB	50313639
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	25.0 %	PMID20156687	ChEMBL
EC50	2710.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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