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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	CHEMBL1084941
Molecular formula	C19H15N3O2
IUPAC name	1-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]indole-2,3-dione
Molecular weight	317.348
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.3
Synonyms	SCHEMBL17207999 VU0365137 BDBM50313639 cid_44251554 1-(4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione VU0365137-1 [ Show all ]
Inchi Key	FZOKIVAOPLLMAV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15N3O2/c1-21-12-15(10-20-21)14-8-6-13(7-9-14)11-22-17-5-3-2-4-16(17)18(23)19(22)24/h2-10,12H,11H2,1H3
PubChem CID	44251554
ChEMBL	CHEMBL1084941
IUPHAR	N/A
BindingDB	50313639
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2710.0 nM	PubChem BioAssay data set	ChEMBL

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