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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL269447
Molecular formulaC28H34N4O2
IUPAC name2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,3'-piperidine]-1'-ylpropan-2-yl]-2-methylpropanamide
Molecular weight458.606
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP3.5
SynonymsBDBM50073039
1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1H-indene-1,3''-(hexahydropyridine)]-1-yl-(1R)-ethyl]-2-amino-2-methylpropanamide
Inchi KeyFYMAEAOHOQXTEX-RIBGEGAISA-N
Inchi IDInChI=1S/C28H34N4O2/c1-27(2,29)26(34)31-24(16-20-17-30-23-11-6-4-9-21(20)23)25(33)32-15-7-13-28(18-32)14-12-19-8-3-5-10-22(19)28/h3-6,8-11,17,24,30H,7,12-16,18,29H2,1-2H3,(H,31,34)/t24-,28?/m1/s1
PubChem CID44269018
ChEMBLCHEMBL269447
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50630.0 nMPMID9925440ChEMBL

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