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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	N-arachidonyl glycine receptor
Species	Homo sapiens (Human)
Gene	GPR18
Synonym	GPCRW G-protein coupled receptor 18 N-arachidonoyol glycine receptor NAGly receptor GPR18
Disease	N/A
Length	331
Amino acid sequence	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProt	Q14330
Protein Data Bank	N/A
GPCR-HGmod model	Q14330
3D structure model	This predicted structure model is from GPCR-EXP Q14330.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2384898
IUPHAR	89
DrugBank	BE0002304

Ligand

Name	6,6-diphenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-one
Molecular formula	C17H14N2OS
IUPAC name	6,6-diphenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-one
Molecular weight	294.372
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.3
Synonyms	CHEMBL3220947 42748-70-9 NSC267021 AC1L81UO DTXSID80313180 6,6-Diphenyl-2,3-dihydroimidazo[2,1-b]thiazol-5(6H)-one 2,3-dihydro-6,6-diphenylimidazo-[2,1-b]-thiazol-5(6h)-one NSC-267021 [ Show all ]
Inchi Key	FYIWQGOPDHFVJD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14N2OS/c20-15-17(13-7-3-1-4-8-13,14-9-5-2-6-10-14)18-16-19(15)11-12-21-16/h1-10H,11-12H2
PubChem CID	320263
ChEMBL	CHEMBL3220947
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	12.0 %	MedChemComm, (2014) 5:5:632	ChEMBL
IC50	<10000.0 nM	MedChemComm, (2014) 5:5:632	ChEMBL
Inhibition	12.0 %	MedChemComm, (2014) 5:5:632	ChEMBL

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