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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL1934123
Molecular formula	C28H29N3O
IUPAC name	N-[(1R)-1'-(9H-carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide
Molecular weight	423.56
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	4.7
Synonyms	BDBM50360704 SCHEMBL14544761
Inchi Key	FYCCIHGGLTVNRX-HHHXNRCGSA-N
Inchi ID	InChI=1S/C28H29N3O/c1-19(32)29-27-17-28(24-8-4-2-7-22(24)27)12-14-31(15-13-28)18-20-10-11-26-23(16-20)21-6-3-5-9-25(21)30-26/h2-11,16,27,30H,12-15,17-18H2,1H3,(H,29,32)/t27-/m1/s1
PubChem CID	10410064
ChEMBL	CHEMBL1934123
IUPHAR	N/A
BindingDB	50360704
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.1 nM	PMID22123324	BindingDB,ChEMBL

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