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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 2
Species	Homo sapiens (Human)
Gene	FFAR2
Synonym	FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 FFA2 receptor [ Show all ]
Disease	Abortion Diabetes
Length	330
Amino acid sequence	MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProt	O15552
Protein Data Bank	N/A
GPCR-HGmod model	O15552
3D structure model	This predicted structure model is from GPCR-EXP O15552.
BioLiP	N/A
Therapeutic Target Database	T28213
ChEMBL	CHEMBL5493
IUPHAR	226
DrugBank	N/A

Ligand

Name	CHEMBL2315528
Molecular formula	C19H15NO2
IUPAC name	3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]phenyl]propanoic acid
Molecular weight	289.334
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.4
Synonyms	SCHEMBL1551054 3-(4-((2-(cyanomethyl)phenyl)ethynyl)phenyl)propanoic acid BDBM50425662
Inchi Key	AMKACOPNIVQTHQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15NO2/c20-14-13-18-4-2-1-3-17(18)11-9-15-5-7-16(8-6-15)10-12-19(21)22/h1-8H,10,12-13H2,(H,21,22)
PubChem CID	67072752
ChEMBL	CHEMBL2315528
IUPHAR	N/A
BindingDB	50425662
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID23294321	ChEMBL

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