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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Homo sapiens (Human)
Gene	GRM4
Synonym	mGluR4 mGlu4 receptor GPRC1D glutamate receptor
Disease	Anxiety disorder Neurological disease
Length	912
Amino acid sequence	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProt	Q14833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T99402
ChEMBL	CHEMBL2736
IUPHAR	292
DrugBank	BE0000833

Ligand

Name	CHEMBL1385271
Molecular formula	C19H15ClN2O4
IUPAC name	N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide
Molecular weight	370.789
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.6
Synonyms	AC1LLYN0 HMS3309B21 N-{4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl}-2-furamide BDBM50336626 MLS002541992 ST50285862 Furan-2-carboxylic acid [4-(2-chloro-benzoylamino)-3-methoxy-phenyl]-amide N-(4-{[(2-chlorophenyl)carbonyl]amino}-3-methoxyphenyl)furan-2-carboxamide AKOS000609572 MCULE-9683550341 N-{4-[(2-chlorophenyl)carbonylamino]-3-methoxyphenyl}-2-furylcarboxamide MolPort-002-013-791 STK134930 HMS2154P09 N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide BAS 08837814 MLS000096735 SMR000074022 N-(4-(2-chlorobenzamido)-3-methoxyphenyl)furan-2-carboxamide ZINC813647 [ Show all ]
Inchi Key	FXIXZADJVWSXHM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15ClN2O4/c1-25-17-11-12(21-19(24)16-7-4-10-26-16)8-9-15(17)22-18(23)13-5-2-3-6-14(13)20/h2-11H,1H3,(H,21,24)(H,22,23)
PubChem CID	1092661
ChEMBL	CHEMBL1385271
IUPHAR	N/A
BindingDB	50336626
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	62.7 %	PMID21247167	ChEMBL
EC50	977.0 nM	PMID21247167	BindingDB,ChEMBL

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