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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL52419
Molecular formulaC33H43NO8S2
IUPAC name4-[2-[2-methoxy-6-propylsulfonyl-4-[(5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenoxy]ethylsulfanyl]-N,N-dimethylaniline
Molecular weight645.826
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP5.9
SynonymsN/A
Inchi KeyFVSDIUCJLOLALY-QBHOUYDASA-N
Inchi IDInChI=1S/C33H43NO8S2/c1-8-17-44(35,36)31-21-23(27-14-13-26(42-27)22-18-28(37-4)32(40-7)29(19-22)38-5)20-30(39-6)33(31)41-15-16-43-25-11-9-24(10-12-25)34(2)3/h9-12,18-21,26-27H,8,13-17H2,1-7H3/t26-,27?/m0/s1
PubChem CID44297597
ChEMBLCHEMBL52419
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition57.0 %Bioorg. Med. Chem. Lett., (1992) 2:2:181ChEMBL
Inhibition66.0 %Bioorg. Med. Chem. Lett., (1992) 2:2:181ChEMBL

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