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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	5-Chlorotryptamine
Molecular formula	C10H11ClN2
IUPAC name	2-(5-chloro-1H-indol-3-yl)ethanamine
Molecular weight	194.662
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.2
Synonyms	VI30020 1H-Indole-3-ethanamine,5-chloro- 2-(5-chloroindol-3-yl)ethylamine AC1Q54BZ CB05124 EU-0011875 Oprea1_792077 ZINC77277 2-(5-Chloro-1H-indol-3-yl)-ethylamine 5-Chloro-1H-indole-3-ethanamine AB03687 ALBB-004962 HMS1613J03 SCHEMBL626030 2-(5-Chloro-1H-indol-3-yl)ethylamine AC1Q3MRZ BBL010651 DTXSID50191073 MCULE-9765462252 ST24039496 W-6526 2-(5-Chloranyl-1~{h}-Indol-3-Yl)ethanamine 3764-94-1 6SO AJ-10403 CBMicro_013645 FT-0635010 SBB002535 2-(5-chloro-1H-indol-3-yl)ethan-1-amine 5-Chloro-1H-indole-3-ethylamine AB1005638 AS-44802 CHEMBL1288716 I10-0590 SMSF0003286 STK386806 1H-Indole-3-ethanamine, 5-chloro- 2-(5-Chloro-1H-indol-3-yl)ethylamine # 5-Cl-T AC1Q54BY BDBM50331286 EINECS 223-184-6 MolPort-001-791-100 ZERO/005526 2-(5-chloro-1H-indol-3-yl) ethanamine 5-Chloro-1H-indole 3-ethanamine AB0086136 AKOS000266602 CCG-20517 FVQKQPVVCKOWLM-UHFFFAOYSA-N SC-75924 2-(5-chloro-1H-indol-3-yl)ethanamine 5-Chloro-1H-indole-3-ethylamine; 2-(5-Chloro-1H-indol-3-yl)ethanamine AC1L2SXD BB 0242423 CTK4H8554 KB-15163 ST096829 [ Show all ]
Inchi Key	FVQKQPVVCKOWLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H11ClN2/c11-8-1-2-10-9(5-8)7(3-4-12)6-13-10/h1-2,5-6,13H,3-4,12H2
PubChem CID	77379
ChEMBL	CHEMBL1288716
IUPHAR	N/A
BindingDB	50331286
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	13.0 nM	PMID8632342	PDSP,BindingDB

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