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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL594740
Molecular formulaC13H10ClFN2OS
IUPAC name1-(4-chlorophenyl)-N-(5-fluoro-1,3-thiazol-2-yl)cyclopropane-1-carboxamide
Molecular weight296.744
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.5
Synonyms1-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)cyclopropanecarboxamide
BDBM50305929
Inchi KeyFVCVNYALLPBLEP-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H10ClFN2OS/c14-9-3-1-8(2-4-9)13(5-6-13)11(18)17-12-16-7-10(15)19-12/h1-4,7H,5-6H2,(H,16,17,18)
PubChem CID46226359
ChEMBLCHEMBL594740
IUPHARN/A
BindingDB50305929
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy>30.0 %PMID20005104ChEMBL
IC50<100000.0 nMPMID20005104BindingDB,ChEMBL

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