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GPCR

NameNeuropeptide Y receptor type 5
SpeciesHomo sapiens (Human)
GeneNPY5R
SynonymNPYY5-R
NPY5-R
NPY-Y5 receptor
neuropeptide Y receptor type 5
food intake receptor
[ Show all ]
DiseaseEating disorder; Obesity
Eating disorder; Obesity; Diabetes
Major depressive disorder
Obesity
Length445
Amino acid sequenceMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProtQ15761
Protein Data BankN/A
GPCR-HGmod modelQ15761
3D structure modelThis predicted structure model is from GPCR-EXP Q15761.
BioLiPN/A
Therapeutic Target DatabaseT20331
ChEMBLCHEMBL4561
IUPHAR308
DrugBankN/A

Ligand

NameCHEMBL75827
Molecular formulaC23H19F3N4O2S
IUPAC nameN-[4-[5-amino-1-(4-methylphenyl)pyrazol-3-yl]phenyl]-4-(trifluoromethyl)benzenesulfonamide
Molecular weight472.486
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP5.0
SynonymsBDBM50103701
N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3-yl)-phenyl]-4-trifluoromethyl-benzenesulfonamide
1-p-Tolyl-3-[4-[4-(trifluoromethyl)phenylsulfonylamino]phenyl]-1H-pyrazole-5-amine
Inchi KeyAMCDXJQVSVQTRW-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H19F3N4O2S/c1-15-2-10-19(11-3-15)30-22(27)14-21(28-30)16-4-8-18(9-5-16)29-33(31,32)20-12-6-17(7-13-20)23(24,25)26/h2-14,29H,27H2,1H3
PubChem CID44312968
ChEMBLCHEMBL75827
IUPHARN/A
BindingDB50103701
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5063.0 nMPMID11527715BindingDB,ChEMBL

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